1.
RSC Adv
; 13(42): 29561-29567, 2023 Oct 04.
Article
in English
| MEDLINE
| ID: mdl-37822662
ABSTRACT
The synthesis of mono- and novel bis-methylated pyrrolo[1,2-a]quinoxalines through the addition of unstable methyl radicals to aryl isocyanides is described contingent upon the reaction conditions employed. The strategy has been effectively employed in the total synthesis of the natural product marinoquinoline A.
2.
Chemistry
; 23(20): 4750-4755, 2017 Apr 06.
Article
in English
| MEDLINE
| ID: mdl-28217842
ABSTRACT
An intramolecular acylal cyclisation (IAC) approach to the synthesis of a range of bicyclic heterocycles is reported. As an example of the utility of the IAC reaction, the methodology was applied in a protecting-group-free five-step total synthesis of (±)-γ-lycorane, incorporating a new intramolecular Heck addition reaction to generate the pentacyclic core structure of the natural product in good yield.