The Prevalence Role of Monocyte Chemoattractant Protein-1 in Hashimoto's Thyroiditis via Various Stimuli Mechanisms.

Hashimoto's thyroiditis (HT) is an autoimmune disease occurred at any age especially in the 30 and 50 years of patient, with time thyroid gland is lost its function, as the lymphocytes produce inflammatory cytokines, have a direct effect on the thyroid gland function. The monocyte chemoattractant protein (MCP) produced by the podocyte and monocyte in response to these stimuli and has a role in the feedback based on thyroid hormones therefore MCP is increased secretion depending on thyroid hormones; also it's increased with enlargement of adipocyte tissue, i.e., in patients with high body mass index (BMI), there is a relationship between Hashimoto's disease and obesity, that has an effect on the thyroid gland function. Obesity have important role on thyrostimulated hormones (TSHs), as it has a great effect on metabolism and expansion of the thyroid gland; researchers have previously found that obese individuals have higher serum TSH levels. The results of the study have reported that MCP 1, TSH, and BMI levels were highly significant increased in sera of G2 compared with G1, while T3 and T4 levels were highly significant decreased in sera of G2 compared with G1 in referring to G1: Healthy control group while G2: HT patients.

Quality assessment of unsaturated iron-binding protein capacity in Iraqi patients undergoing hemodialysis.

Hemodialysis is autoimmune disease result from inflammation, oxidative stress, and fibrosis. It is characterized by renal glomeruli damage, podocyte injury, tubule interstitial, and proteinuria. Electrolyte balance is the main function of the renal and any form of electrolyte disorders may lead to excess blood volume, hypertension, and difficulty in maintaining natural blood sodium. Renal erythropoietin has an important role in the balance of vascular active substances, such as prostaglandins and thromboxanes; therefore, patients undergoing hemodialysis observe decreased production of erythropoietin with iron loss through hemodialysis machine as well as weakened iron absorption and mobilization from the intestine to the bloodstream. Ferritin, total iron-binding capacity (TIBC), unsaturated iron-binding protein capacity (UIBC), iron free, and transferrin are used to confirm iron status. According the clinical characterization of the results, no normality was observed in patients undergoing hemodialysis. There was hypertension, anemia, lean symptoms and equal distribution of age parallel with developed disease, there was significant increased in renal function except albumin, it was decreased in the patients compared with control groups. In addition, there was a decreased level of iron status in all parameters such as packed cell volume (%), TIBC, UIBC, iron free, and transferrin except ferritin; there was an increased level of iron status in all parameters in patients compared with control groups.