ABSTRACT
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumour of the skin, characterised by an aggressive clinical course. The incidence of this rare neoplasia is rapidly increasing. Herein we report our experience with a patient who developed a MCC of the inguinal region.
Subject(s)
Carcinoma, Merkel Cell/diagnosis , Skin Neoplasms/diagnosis , Aged, 80 and over , Carcinoma, Merkel Cell/radiotherapy , Female , Humans , Skin Neoplasms/radiotherapyABSTRACT
Prognostic significance of the skeletal lesions in multiple myeloma. Fifty-two patients with multiple myeloma have been analysed and relations between bone X-ray changes and several clinical biohumoral parameters and survival have been found. Our studies show no correlation between the extent of skeletal lesions and the seriousness of anaemia, or between bone marrow infiltration and renal involvement. The results also show that patients with apparently normal bones may also have serious anaemia, wide bone marrow infiltration and serious renal lesions rapidly leading to a poor prognosis. Comparison of survival curves, according to the grade of bone X-ray changes at presentation, shows no significant difference: the grade of bone lesions at diagnosis does not seem to considerably influence survival.
Subject(s)
Bone Diseases , Multiple Myeloma , Aged , Bone Diseases/blood , Bone Diseases/mortality , Bone Diseases/pathology , Female , Humans , Male , Middle Aged , Multiple Myeloma/blood , Multiple Myeloma/mortality , Multiple Myeloma/pathology , Neoplasm Staging , PrognosisSubject(s)
Lymphoma, Non-Hodgkin/pathology , Adult , Aged , Female , Humans , Lymphoma, Non-Hodgkin/mortality , Male , Middle Aged , Prognosis , Retrospective StudiesSubject(s)
Bone Marrow/pathology , Multiple Myeloma/pathology , Humans , Neoplasm Staging , Plasma Cells/pathology , PrognosisSubject(s)
Leukemia, Lymphoid/pathology , Adult , Aged , Female , Humans , Leukemia, Lymphoid/mortality , Male , Middle Aged , Neoplasm StagingABSTRACT
One hundred and twenty adult patients with high temperatures (greater than or equal to 38 degrees C) brought about by influenza viruses or other conditions were randomly treated with two different antipyretics: a) a 25 mg sodium diclofenac tablet (Novapirina) every 12 hours for 2 consecutive days; b) a 500 mg tablet of acetylsalicylic acid (Aspirin) every 8 hours for 2 consecutive days. Antipyretic action (assessed at 6 hours following the first administration) was found to be equally rapid and consistent in both cases but significantly longer-lasting in the Novapirina-treated group than the Aspirin-treated group (p less than 0.01). Mean temperature changes over the 48 hours of observation and the over-all judgement on the antipyretic effect expressed at the end of each day of treatment were similar for both groups and good in all cases. The antiphlogistic-painkilling properties of both drugs were found to be effective in improving the symptomatology accompanying the high temperature during the course of the bout of influenza. The effectiveness/tolerability ratio was found to be satisfactory for both groups: only one case of gastric intolerance to Novapirina was recorded and five cases of gastric intolerance to Aspirin.
