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Clin Infect Dis ; 61(8): 1304-6, 2015 Oct 15.
Article in English | MEDLINE | ID: mdl-26082511

ABSTRACT

Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.


Subject(s)
Antiviral Agents/therapeutic use , Coinfection , Hepatitis B virus/physiology , Hepatitis B/complications , Hepatitis C, Chronic/complications , Hepatitis C, Chronic/drug therapy , Simeprevir/therapeutic use , Sofosbuvir/therapeutic use , Administration, Oral , Antiviral Agents/administration & dosage , Drug Therapy, Combination , Hepatitis B/virology , Hepatitis C, Chronic/virology , Humans , Male , Middle Aged , Risk Factors , Simeprevir/administration & dosage , Sofosbuvir/administration & dosage
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