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Preliminary investigations on the synthesis and antitumor activity of 3(2H)-furanones.
Rappai, J P; Raman, V; Unnikrishnan, P A; Prathapan, S; Thomas, S K; Paulose, C S.
Bioorg Med Chem Lett ; 19(3): 764-5, 2009 Feb 01.
Article in English | MEDLINE | ID: mdl-19121938

ABSTRACT

Two triaryl-3(2H)-furanones were synthesized and their antitumor activity was evaluated. These compounds inhibited the proliferation of DLA cell line in vitro. In vivo studies also showed that these compounds were active against tumor cell proliferation.


Subject(s)
Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/pharmacology , Chemistry, Pharmaceutical/methods , Furans/chemistry , Acetic Acid/chemistry , Cell Line, Tumor , Cell Proliferation , DNA/metabolism , Dose-Response Relationship, Drug , Drug Design , Drug Screening Assays, Antitumor , Humans , Models, Chemical , Oxygen/chemistry , Structure-Activity Relationship , Styrene/chemistry
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