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1.
Adv Skin Wound Care ; 33(10S Suppl 1): S3-S10, 2020 Oct.
Article in English | MEDLINE | ID: mdl-32932289

ABSTRACT

BACKGROUND: Turning and repositioning devices (TRDs) help to reduce strain on caregivers, but clinicians question their effects on humidity and temperature (microclimate) at the skin surface that may increase risk of pressure ulcers. OBJECTIVE: To pilot the use of a standard test for support surfaces to compare microclimate at the skin surface in three scenarios: (1) on a low-air-loss (LAL) surface, (2) on a representative TRD with a basic underpad (TRDU) placed on a LAL surface, and (3) on a negative control with full occlusion. The results are designed to inform clinical decision-making in using a TRD on a LAL surface and the viability of using this test to study TRDs. DESIGN: Measuring humidity and temperature at the device-surface interface using a heated moisture-exuding bronze thermodynamic human model in a laboratory setting. MAIN OUTCOME MEASURE: Humidity and temperature levels across 3 hours 15 minutes of continuous loading with a 45-second complete unloading to simulate a position change at 3 hours. MAIN RESULTS: Relative humidity on the TRDU was below that on the LAL surface for the first 110 minutes and was markedly lower than the negative control for the remainder of humidity testing. Temperature on the TRDU was well below the negative control and negligibly higher than the surface alone throughout testing. The position change enhanced the effects of the TRDU. CONCLUSIONS: The support surface standard test appears useful in evaluating TRDs. This TRD along with the basic underpad is more comparable to a LAL surface than to full occlusion in managing the microclimate of the skin and pressure ulcer risk.


Subject(s)
Air Conditioning/standards , Bedding and Linens/standards , Humidity/prevention & control , Patient Positioning/methods , Pressure Ulcer/prevention & control , Skin Temperature , Humans , Quality Improvement , Temperature
2.
Adv Skin Wound Care ; 24(8): 357-68, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21768787

ABSTRACT

OBJECTIVE: This study investigated clinical outcomes in chronic nonhealing wounds following the short-term use of an enhanced, near-physiological concentration of platelet-rich plasma (PRP) gel (AutoloGel System, Cytomedix, Inc, Gaithersburg, Maryland). DESIGN: Study design was a large, observational case series using a multicenter registry database (all wounds included), which compared different populations within the database. SETTING: Thirty-nine centers contributed to the registry, including long-term acute-care centers, outpatient clinics, a durable medical equipment company, a home health agency, and a long-term-care center. PATIENTS: The target population included 285 chronic wounds (patient n = 200). Wound etiologies included diabetic, pressure, or venous ulcer; dehisced, surgical, or traumatic wound; and wounds of other etiologies. INTERVENTION: Therapeutic, PRP gel is produced from patient blood utilizing autologous platelets and plasma that contribute growth factors, cytokines, and chemokines, in a fibrin matrix. MAIN MEASURES: Area and volume of the wound and the linear total of undermining and sinus tracts/tunneling were calculated. Clinical relevance was determined by analyzing outcomes in wounds that responded to treatment. MAIN RESULTS: A positive response occurred in 96.5% of wounds within 2.2 weeks with 2.8 treatments. In 86.3% of wounds, 47.5% area reduction occurred, and 90.5% of wounds had a 63.6% volume reduction. In 89.4% undermined and 85.7% of sinus tracts/tunneling wounds, 71.9% and 49.3% reductions in linear total were observed, respectively. CONCLUSION: In chronic wounds recalcitrant to other treatments, utilization of PRP gel can restart the healing process. Rapid treatment response was observed in 275 of 285 wounds, and the magnitude of response was consistently high, with statistically significant outcomes reported for various subgroups.


Subject(s)
Biological Dressings/statistics & numerical data , Platelet-Rich Plasma , Wound Healing , Wounds and Injuries/therapy , Ambulatory Care/statistics & numerical data , Case-Control Studies , Chronic Disease , Diabetic Foot/therapy , Gels , Humans , Pressure Ulcer/therapy , Registries , Treatment Outcome , United States/epidemiology , Varicose Ulcer/therapy , Wounds and Injuries/epidemiology
3.
Int Wound J ; 8(2): 187-95, 2011 Apr.
Article in English | MEDLINE | ID: mdl-21385319

ABSTRACT

The objective of the study was to investigate the use of a 1·3 times normal platelet concentration platelet-rich plasma (PRP) gel to move chronic wounds towards healing in persons with spinal cord injury (SCI). The study design was a case series of 20 persons with SCI with non healing wounds. The outcome measures were, in wound area, volume, undermining and sinus tracts/tunnels (ST/Ts), calculated average, (i) percent of change from baseline, (ii) change per day from baseline, (iii) number of treatments and (iv) number of weeks. In a mean of 4·0, after treatments over 3·4 weeks, the wounds closed on an average of 47·9% in area and 56·0% in volume. Undermining closed on an average of 31·4% using 3·5 treatments over 2·6 weeks. ST/Ts closed on an average of 26·1% after 2·3 treatments over 1·5 weeks. Clinical relevance by percent of positive responders and their response: in area, 90·0% of the subjects responded positively, the average reduction was 53·8%. In volume, 90·0% responded, with an average reduction of 67·3%. Of four subjects with undermining, 75% closed 47·0% on average. Of the three with ST/Ts, 100% closed 26·1% on average. Average haemoglobin and haematocrit levels were below normal. To conclude, 1·3× PRP gel appears to progress chronic, non healing wounds in SCI patients into the granulation phase of healing quickly. Review of the literature shows these results may not be applied to all PRP preparations.


Subject(s)
Blood Platelets/metabolism , Platelet-Rich Plasma , Skin/injuries , Spinal Cord Injuries/therapy , Wound Healing/physiology , Administration, Cutaneous , Adult , Aged , Follow-Up Studies , Gels , Humans , Middle Aged , Platelet Count , Retrospective Studies , Skin/metabolism , Spinal Cord Injuries/metabolism , Time Factors , Treatment Outcome
5.
Ostomy Wound Manage ; 56(6): 36-44, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20567053

ABSTRACT

Chronic wounds are characterized by a long inflammatory phase that hinders regenerative wound healing. The purpose of this prospective case series was to evaluate how a physiologically relevant concentration of an autologous platelet-rich plasma (PRP) gel affects initial wound healing trajectories of chronic, nonhealing wounds of various etiologies and in different care settings. Using convenience sampling methods, 49 patients (average age: 60.6 years, SD 14.7) with 65 nonhealing wounds (mean duration 47.8 weeks, range 3 to 260) at eight long-term acute care (LTAC) hospitals and three outpatient foot or wound clinics who were prescribed PRP gel for their nonhealing wound were enrolled. The majority of patients had low albumin, hematocrit, and/or hemoglobin levels. After wound assessments and measurements were obtained and the gel prepared, a skin barrier was applied to the periwound skin and the gel applied and protected with cover dressings. The most common wounds were pressure ulcers (n = 21), venous ulcers (n = 16) and diabetic foot ulcers (n = 14). Mean wound area and volume were 19 cm2 (SD 29.4) and 36.2 cm3 (SD 77.7), respectively. Following a mean of 2.8 (SD 2.4) weeks with 3.2 (SD 2.2) applications, reductions in wound volume (mean 51%, SD 43.1), area (39.5%, SD 41.2), undermining (77.8%, SD 28.9), and sinus tract/tunneling (45.8%, SD 40.2) were observed. For all wound etiologies, 97% of wounds improved. The results of this study suggest the application of this PRP gel can reverse nonhealing trends in chronic wounds.


Subject(s)
Platelet-Rich Plasma , Wounds and Injuries/therapy , Ambulatory Care , Chronic Disease , Debridement , Diabetic Foot/therapy , Gels , Humans , Middle Aged , Platelet-Rich Plasma/physiology , Pressure Ulcer/therapy , Prospective Studies , Skilled Nursing Facilities , Skin Care/methods , Transplantation, Autologous , Treatment Outcome , Varicose Ulcer/therapy , Wound Healing , Wounds and Injuries/diagnosis , Wounds and Injuries/etiology
6.
J Am Col Certif Wound Spec ; 2(1): 4-8, 2010.
Article in English | MEDLINE | ID: mdl-24527136

ABSTRACT

Air-fluidized support surface therapy has many drawbacks, such as dehydration, in an already difficult recovery for those wound patients who have undergone flap and graft surgery. In addition, patient care and handling are also problematic. Patients complain of discomfort, and the instability of the surface interferes with patient stability in side lying and semi-Fowler's positions. Alternative support surfaces can be considered for postflap or postgraft patients. Such technologies as alternating pressure, low-air-loss, and therapeutic nonpowered, advanced, and lateral rotation surfaces are widely used for pressure management in high-risk patients and those with existing pressure ulcers. These surfaces must be used within a total pressure ulcer management program that includes frequent turning and repositioning, skin and ulcer care according to evidence-based protocols, patient and caregiver instruction, nutrition, and offloading and positioning. The proposed recommendations require more research on the relative effectiveness of less expensive and more user-friendly support surfaces such as low-air-loss and nonpowered advanced support surfaces and is necessary in order to conclusively recommend one type of surface over another. However, at this time the available clinical studies and opinions remain positive.

7.
Int Wound J ; 5(3): 435-44, 2008 Jun.
Article in English | MEDLINE | ID: mdl-18205787

ABSTRACT

There are many metabolic and physiological changes that happen to the tissues below the level of a spinal cord injury. These deficits are examined in relation to the series of events that has to take place for wound healing - the "wound healing cascade". The conclusion is that every step of the wound healing process is impaired by the physiological deficits inherent post-spinal cord injury. This may explain, in part, why pressure ulcers on these patients are so difficult to close and to maintain closed.


Subject(s)
Pressure Ulcer/etiology , Spinal Cord Injuries , Wound Healing/physiology , Bed Rest/adverse effects , Blood Coagulation/physiology , Blood Pressure/physiology , Collagen/physiology , Evidence-Based Medicine , Extracellular Matrix/physiology , Fibroblasts/physiology , Fibronectins/physiology , Glycosaminoglycans/physiology , Humans , Inflammation , Microcirculation , Oxygen/physiology , Pressure Ulcer/prevention & control , Receptors, Adrenergic , Recurrence , Risk Factors , Skin Care , Spinal Cord Injuries/complications , Spinal Cord Injuries/metabolism , Spinal Cord Injuries/physiopathology
8.
Ostomy Wound Manage ; 53(11): 28-39, 2007 Nov.
Article in English | MEDLINE | ID: mdl-18057444

ABSTRACT

The number and variety of wound care organizations and certification programs have increased considerably in recent years. Many healthcare professionals interested in pursuing certification, employers who want to hire them, and the public at large are confused about the plethora of certification designations, program names, and requirements. Some of the largest wound care organizations in the US support or develop educational programs and meetings or support credentialing programs. Two of the four largest credentialing organizations are accredited. Information about the effect of credentialing on healthcare provider knowledge and clinical skills is not available and standards are needed to help healthcare providers and employers decide which program best serves their needs. Most importantly, research to ascertain the effects of educational programs and credentialing on patient outcomes must be conducted to help improve the quality of care and substantiate the goals of the credentialing programs.


Subject(s)
Certification , Wounds and Injuries/nursing , Humans , Organizations
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