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1.
Pak J Pharm Sci ; 32(4(Supplementary)): 1767-1772, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31680071

ABSTRACT

A chemically preserved food has raised mental health issues. Abnormalities in liver and kidney functions have been reported from mentally imbalanced individuals. This study was focused on finding anxiety issues and biochemistry alterations in brain tumor patients and in controls. The levels of liver & kidney enzymes were compared in both groups through Mann-Whitney U test. Kendall's tau-b correlation was conducted to determine that is there any relationship between anxiety levels and biochemistry parameters in both groups. There was more occurrence of severe anxiety levels (58%) in brain tumor patients. There were more mood swings in CG (64%) as compared to BP (48%). Less sleeping pattern was found in CG (42%) as compared to BP (37%). More patients (58%) were having severe anxiety levels as compared to CG (52%). 73% patients were having low levels of alkaline phosphatase (AP). 52% individuals in CG were having low levels of AP. AP was found significantly associated with anxiety levels in brain tumor patients only. A nutrient deprived food from preservation can reduce levels of alkaline phosphatase. This can impact metabolism of necessary minerals for proper brain function. This epidemiological study reports a significant association between anxiety and reduced AP levels.


Subject(s)
Antipsychotic Agents/adverse effects , Brain Neoplasms/physiopathology , Food Additives/adverse effects , Kidney/drug effects , Liver/drug effects , Water/adverse effects , Adolescent , Adult , Aged , Aged, 80 and over , Alkaline Phosphatase/metabolism , Anxiety/chemically induced , Brain Neoplasms/metabolism , Case-Control Studies , Child , Epidemiologic Studies , Female , Humans , Male , Middle Aged , Young Adult
2.
Pak J Pharm Sci ; 32(6(Supplementary)): 2859-2864, 2019 Nov.
Article in English | MEDLINE | ID: mdl-32024625

ABSTRACT

Frozen food chemicals contain neurotoxins which disturb electrolyte levels. Altered electrolyte levels can induce mental illnesses. This study was focused on finding the prevalence of depression, dementia, intake of antidepressants and electrolytic alterations in brain cancer (BC) patients and in control group (CG) who were taking frozen and canned food. The levels of electrolytes were compared in both groups through Mann-Whitney U test. The Odds Ratio (OR) and Relative Risks (RR) were calculated of having a specific occurrence or condition of brain cancer patients vs. controls. Majority (41.42%) patients were from the age group 33-57 years. There were 52% male and 47% female patients. There was more occurrence of dementia (41%) and depression (6%) in patients as compared to CG. 94% patients were found with dementia. 32% patients were having low levels of sodium and 43% were having low levels of potassium. High levels of potassium (26%) were found in CG. 76% patients and 73% controls were taking canned food in moderation. 69% patients and 50% controls were taking frozen food in moderation. The potassium levels (p value: 0.00001) and sodium levels (p value: 0.01468) were found at significant difference in brain cancer patients and control group. Statistically significantly higher odds of outcome (OR>1) and increased relative risks (RR) were reported in dementia, depression and intake of anti-depressants for BC vs. CG. This epidemiological study reports hyponatremia as a significantly different parameter between brain cancer patients and controls. Food's chemicals induce hyponatremia, which can disturb mental states to develop different neurological conditions.


Subject(s)
Brain Neoplasms/physiopathology , Dementia/etiology , Depression/etiology , Frozen Foods/adverse effects , Hyponatremia/chemically induced , Adolescent , Adult , Aged , Antidepressive Agents/therapeutic use , Brain Neoplasms/metabolism , Case-Control Studies , Child , Dementia/metabolism , Depression/drug therapy , Depression/metabolism , Female , Humans , Hyponatremia/metabolism , Male , Middle Aged , Odds Ratio , Potassium/metabolism , Prevalence , Risk , Sodium/metabolism , Young Adult
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