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Molecules ; 18(8): 8845-57, 2013 Jul 25.
Article in English | MEDLINE | ID: mdl-23892631

ABSTRACT

In general, benzothiazole derivatives have attracted great interest due to thier pharmaceutical and biological importance. New 2-amino-6-arylbenzothiazoles were synthesized in moderate to excellent yields via Suzuki cross coupling reactions using various aryl boronic acids and aryl boronic acid pinacol esters and the antiurease and nitric oxide (NO) scavenging activity of the products were also examined. The most active compound concerning urease enzyme inhibition was 6-phenylbenzo[d]thiazole-2-amine 3e, with an IC50 value of 26.35 µg/mL. Compound 3c, 6-(4-methoxyphenyl) benzo[d]thiazole-2-amine, exhibited the highest nitric oxide percentage scavenging at 100 µg/mL.


Subject(s)
Benzothiazoles/chemical synthesis , Palladium/chemistry , Urease/chemistry , Amines , Benzothiazoles/chemistry , Boronic Acids/chemistry , Catalysis , Free Radical Scavengers/chemistry , Molecular Structure , Nitric Oxide/chemistry , Urease/antagonists & inhibitors
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