ABSTRACT
Experimental invasion of white outbred mice with Nippostrongylus brasiliensis show, that chemotherapeutic effectiveness of medamin is changing in various developmental stages of this helminth. Larva of the fourth phase is most sensitive to medamin; adult worm, especially in the beginning of oviposition, is less sensitive. Chemotherapeutic effect of medamin is increasing with prolongation of therapeutic period, increase of daily doses and degree of its dispersiveness.
Subject(s)
Antinematodal Agents/administration & dosage , Benzimidazoles/administration & dosage , Carbamates , Nippostrongylus/drug effects , Animals , Disease Models, Animal , Drug Evaluation, Preclinical , Larva/drug effects , Larva/growth & development , Mice , Nippostrongylus/growth & development , Strongylida Infections/drug therapy , Strongylida Infections/parasitology , Time FactorsABSTRACT
Experiments with the model of Nippostrongylus brasiliensis and white outbred mice showed that vermox and albendazole are highly effective anthelmintics in nippostrongyliasis. The ED50 of albendazole for 7 days invasion (adult worms) is 148.9 times higher than for 4 days (fourth instar larvae) and 25.1 times higher than for 2 days (third instar larvae). The ED90/ED10 ratio for albendazole is 1.4, 4.4, and 12.4 at days 7, 4, and 2, respectively. At the adult stage, susceptibility to anthelmintics (vermox and albendazole) increases with age.
Subject(s)
Albendazole/therapeutic use , Mebendazole/therapeutic use , Nematode Infections/drug therapy , Nippostrongylus , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Larva/drug effects , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Mice, Inbred DBA , Nematode Infections/parasitology , Nippostrongylus/drug effects , Time FactorsABSTRACT
A comparison of the efficacy of albendazole, medamine, and Vermox using an experimental model of Trichocephalus muris in DBA-2 mice showed that Vermox was most effective at all stages of the parasite development. The therapeutic activity of albendazole and medamine depends on daily dose, its dividing through the day and the duration of the treatment. At larval stages of T. muris complete recovery might be achieved using a daily dose of 25 mg/kg for albendazole and 150 mg/kg for medamine, but at the adult stage the doses of the drugs should be 3-4 times higher to achieve 100% effect. The resistance of T. muris to the drugs especially increases at the beginning of egg production.
