ABSTRACT
This article summarizes the current status of 1H MRS in detecting and quantifying a boron neutron capture therapy (BNCT) boron carrier, L-p-boronophenylalanine-fructose (BPA-F) in vivo in the Finnish BNCT project. The applicability of 1H MRS to detect BPA-F is evaluated and discussed in a typical situation with a blood containing resection cavity within the gross tumour volume (GTV). 1H MRS is not an ideal method to study BPA concentration in GTV with blood in recent resection cavity. For an optimal identification of BPA signals in the in vivo 1H MR spectrum, both pre- and post-infusion 1H MRS should be performed. The post-infusion spectroscopy studies should be scheduled either prior to or, less optimally, immediately after the BNCT. The pre-BNCT MRS is necessary in order to utilise the MRS results in the actual dose planning.
Subject(s)
Boron Compounds/blood , Boron Neutron Capture Therapy , Fructose/analogs & derivatives , Magnetic Resonance Spectroscopy/methods , Adult , Aged , Boron/therapeutic use , Boron Compounds/analysis , Brain Neoplasms/pathology , Brain Neoplasms/radiotherapy , Carcinoma/pathology , Carcinoma/radiotherapy , Female , Finland , Fructose/analysis , Fructose/blood , Glioblastoma/pathology , Glioblastoma/radiotherapy , Humans , Hydrogen , Isotopes/therapeutic use , Male , Neoplasm Recurrence, Local/pathology , Neoplasm Recurrence, Local/radiotherapy , Paranasal Sinus Neoplasms/pathology , Paranasal Sinus Neoplasms/radiotherapy , Phantoms, Imaging , Plasma , Radiopharmaceuticals/therapeutic useABSTRACT
Boron biodistribution after intravenous infusion of 4-dihydroxyborylphenylalanine-fructose (BPA-F) complex was investigated in six dogs. Blood samples were evaluated during and following doses of 205 and 250 mg/kgbw BPA in a 30 min infusion, and 500 mg/kgbw in a 1h infusion. Samples from whole blood, urine, brain and other organs were analysed for boron content after varying times following the onset of infusion. The whole blood boron concentrations declined from 27 to 8.4 ppm over the period of 39-165 min after the onset of infusion and the levels increased from 1.9 to 12 ppm in the grey matter of the brain over the same period. The boron concentrations in whole blood decreased steadily, whereas the boron values in brain tissue rose steadily with time. It was concluded that whole blood boron concentrations do not seem to reflect accurately the boron concentration in brain tissue at respective time points.