ABSTRACT
Alprazolam is a widely used antianxiety agent, yet relatively little is known about the relationship between chronic oral doses and steady-state plasma levels. This study examines the relationship over a wide range of therapeutic doses. We conducted a parallel, double-blind, placebo-controlled study in 36 patients with agoraphobia with panic attacks, or panic disorder with limited phobic avoidance based on DSM-III criteria. Patients received alprazolam (N = 25) or placebo (N = 11) beginning at 1 mg/day and increased weekly until either a maximum tolerated dose or 10 mg/day was achieved. Dosages were then gradually tapered according to a predetermined schedule. The entire study period lasted 14 weeks. Laboratory and clinical assessments were conducted weekly. Doses up to 6 mg/day were tolerated by 80% of patients on alprazolam and doses of 10 mg/day were tolerated by 40% of patients. Twenty-seven percent of the placebo patients reached 10 tablets/day. In the alprazolam group, the principal cause of intolerance was sedation. Throughout the study no significant changes in vital signs or laboratory parameters were observed. Steady state alprazolam, 4-hydroxy alprazolam, and alpha-hydroxy alprazolam plasma levels were linearly related to dose. A 1 mg dosage increment produced, on the average, a corresponding 10 ng/ml increase in steady state level of the parent drug. Significant response was observed in subjects who achieved concentrations greater than 20 ng/ml, with a maximum of 81% of the samples classified as responders within the 60 ng/ml and above group.(ABSTRACT TRUNCATED AT 250 WORDS)
Subject(s)
Agoraphobia/drug therapy , Alprazolam/administration & dosage , Anxiety Disorders/drug therapy , Fear/drug effects , Panic/drug effects , Adult , Agoraphobia/blood , Agoraphobia/psychology , Alprazolam/pharmacokinetics , Anxiety Disorders/blood , Anxiety Disorders/psychology , Clinical Trials as Topic , Dose-Response Relationship, Drug , Double-Blind Method , Female , Humans , Male , Middle Aged , Personality TestsSubject(s)
Composite Resins , Crowns , Dental Alloys , Dental Bonding , Dental Cements , Humans , Post and Core TechniqueABSTRACT
This subject list of 116 dental books and 20 dental journals is intended to help the dental book committee and the librarian of a small health sciences library achieve a balanced collection of dental books and journals. Cost of books totals 2,619.38 dollars, that of journals is 531.50 dollars, making a total of 3,150.88 dollars. Cost of starred books totals 1,083.75 dollars, that of starred journals is 134.00 dollars, making a total of 1,217.75 dollars.
Subject(s)
Bibliographies as Topic , Book Selection , Libraries, DentalABSTRACT
An indirect technique to prepare a multirooted pulpless tooth to receive a crown is presented. The crown also may be made on the newly completed core and its die. The procedure promotes the use of a commercial dental laboratory. The system, which uses divergent roots, results in a cast core having maximum retention.
Subject(s)
Crowns , Post and Core Technique , Cementation , Dental Casting Technique , Dental Cavity Preparation/methods , Dental Impression Technique , Dental Pulp Cavity/anatomy & histology , HumansABSTRACT
This subject list of 109 dental books and 20 dental journals is intended to help the dental book committee and the librarian of a small health sciences library achieve a balanced collection of dental books and journals. Cost of books totals $2,180.00, that of journals is $571,00, making a total of $2,751.00. Cost of starred books totals $927.30, that of starred journals is $109.50, making a total of $1,036.80.