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Eksp Klin Farmakol ; 77(7): 31-4, 2014.
Article in Russian | MEDLINE | ID: mdl-25322652

ABSTRACT

Comparative analysis of the pharmacokinetics and bioequivalence of a new dipeptide anxiolytic compound GB-115 in three drug forms for peroral administration, developed in the experimental technology department of the Institute of pharmacology RAMS, was carried out. Three drug forms of GB-115 and a micronized substance of this compound were different in composition and technology of production. As a result of the investigations of GB-115 pharmacokinetics, drug form No. 2 (with a relative bioequivalence of 192%) showed advantages in comparison to the micronized parent substance and two other drug forms (bioequivalence, 53 and 117%) and can be recommended for further pharmacological studies.


Subject(s)
Anti-Anxiety Agents/pharmacokinetics , Dipeptides/pharmacokinetics , Animals , Anti-Anxiety Agents/pharmacology , Biological Availability , Dipeptides/pharmacology , Male , Rats
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