ABSTRACT
Most clinicians consider duodenum ulcer as a psychosomatic disease. Objective: To show the interdependence of this condition and mental disorders and their relation to disturbances of melatonin production . Materials and Methods: 15 patients with seasonal DU and 15 healthy subjects of the control group were examined during 3 years using laboratory, endoscopic, and standard psychodiagnostic methods. Results. It was found that all patients with exacerbation of DU experienced enhanced anxiety, reduced background mood, and impaired quality of life based on general health and mental health scoring scales. The circadian rhythm of melatonin production was markedly distorted throughout the observation period but especially during exacerbations of the disease. Conclusions. The results indicate a high degree of correlation between DU and mental disorders caused by impaired production of melatonin. It suggests common etiological mechanisms of DU and psychosomatic symptom complex.
Subject(s)
Anxiety , Depression , Duodenal Ulcer , Melatonin , Psychophysiologic Disorders , Quality of Life , Anxiety/diagnosis , Anxiety/physiopathology , Chronobiology Phenomena , Circadian Rhythm , Depression/diagnosis , Depression/physiopathology , Duodenal Ulcer/diagnosis , Duodenal Ulcer/physiopathology , Duodenal Ulcer/psychology , Duodenoscopy/methods , Female , Humans , Male , Melatonin/analysis , Melatonin/biosynthesis , Middle Aged , Psychological Tests , Psychophysiologic Disorders/diagnosis , Psychophysiologic Disorders/metabolism , Psychophysiologic Disorders/physiopathology , Statistics as Topic , Surveys and QuestionnairesABSTRACT
The review is focused on recent publications concerning examination of patients with gastroenterological pathology and the use of capsule endoscopy for diagnostics ofsmall bowel diseases. It is shown that radiological methods and enteroscopy are second line diagnostic tools while capsule endoscopy becomes the method ofchoice for the detection of latent gastrointestinal bleeding, tumours, Crohn's disease, and other enteropathies. The advantages of capsule enteroscopy include high effectiveness, atraumaticity, low frequency of complications and possibility to conduct studies without anesthesia. Much attention is given to indications and contraindicationsfor capsule endoscopy and methods of patient preparationfor this procedure.
Subject(s)
Capsule Endoscopy , Capsule Endoscopy/history , Capsule Endoscopy/methods , Capsule Endoscopy/trends , History, 20th Century , History, 21st Century , HumansSubject(s)
Duodenal Ulcer/drug therapy , Gastric Acid/metabolism , Gastric Mucosa/drug effects , Neurosecretory Systems/drug effects , Proton Pump Inhibitors/therapeutic use , Stomach Ulcer/drug therapy , Duodenal Ulcer/metabolism , Duodenal Ulcer/pathology , Follow-Up Studies , Gastric Mucosa/metabolism , Gastric Mucosa/pathology , Humans , Neurosecretory Systems/metabolism , Stomach Ulcer/metabolism , Stomach Ulcer/pathology , Time Factors , Treatment OutcomeABSTRACT
Changes in the antral gastric mucosa of patients with doudenal ulcer after a long-term administration of antisecretory agents were studied. The subjects were five patients with a different duration of the disease. The methods applied included light and electron microscopy of tissue samplings taken from the antral part of the stomach during the periods of exacerbation and remission. In addition to well-known morphological changes, cellular principalis not typical of antral gastric mucosa were found in one patient during exacerbation and remission periods.
Subject(s)
Duodenal Ulcer/drug therapy , Gastric Acid/metabolism , Gastric Mucosa/ultrastructure , Histamine H2 Antagonists/therapeutic use , Pyloric Antrum/pathology , Adolescent , Aged , Biopsy , Duodenal Ulcer/metabolism , Duodenal Ulcer/pathology , Endoscopy, Gastrointestinal , Female , Follow-Up Studies , Gastric Mucosa/drug effects , Humans , Male , Microscopy, Electron , Middle Aged , Pyloric Antrum/drug effects , Pyloric Antrum/metabolism , Severity of Illness Index , Treatment OutcomeABSTRACT
Ultrasonography by an original technique, consisting in stomach examination after fasting and upon contrasting, was performed in 10 cases in addition to conventional radiological and endoscopic techniques for diagnostics of gastric leiomyomas. An anechogenous mass originating from the muscular layer of the stomach was considered an evidence of leiomyoma. Advantages of ultrasonography over other methods used for the diagnostics of gastric leiomyomas include a possibility to evaluate the whole gastric wall, its layers, and the internal structure of the formation. This provides additional possibilities for differential diagnostics, including cases of malignization.
Subject(s)
Leiomyoma/diagnostic imaging , Stomach Neoplasms/diagnostic imaging , Stomach/diagnostic imaging , Adult , Biopsy , Diagnosis, Differential , Endoscopy, Gastrointestinal , Female , Humans , Leiomyoma/pathology , Male , Reproducibility of Results , Stomach/pathology , Stomach Neoplasms/pathology , UltrasonographySubject(s)
Endoscopy, Digestive System/methods , Laser Therapy , Peptic Ulcer/surgery , Adult , Female , Humans , Male , Middle Aged , Treatment OutcomeABSTRACT
The intensity of protein synthesis (incorporation/pool) is usually low in normal stomach mucosa and enhanced in exacerbation of peptic ulcer; following the effective laser therapy it decreases only in one third of cases. Therefore the scarring of ulcer not always coincides with the normalization of protein synthesis. The results characterize also the community of reactions in stomach and duodenal mucose membranes. The changes in protein synthesis intensity following the laser irradiation depended neither on the initial size of ulcer nor on the age of patient and the total duration of disease.
