Subject(s)
Arteriosclerosis/pathology , Disease Models, Animal , Animals , Animals, Zoo , Aorta/pathology , Arteriosclerosis/etiology , Bird Diseases/pathology , Birds , Cerebral Arteries/pathology , Chickens , Coronary Vessels/pathology , Dog Diseases/pathology , Dogs , Haplorhini , Poultry Diseases/pathology , Rabbits , Rats , Rodent Diseases/pathology , Swine , Swine Diseases/pathology , TurkeysABSTRACT
Dwarfing of swine maintained in large groups with relatively little space per animal may be attributed to psychosocial factors. Intramural coronary arteriosclerosis developed at approximately the same rate in dwarfed and normally developing animals. Lesions in arteries of the left posterior papillary muscle were more advanced than in the left anterior papillary muscle of the same animal, irrespective of its growth rate, and often were more advanced than in swine twice as old.
Subject(s)
Coronary Disease/veterinary , Dwarfism/veterinary , Swine Diseases/pathology , Animals , Coronary Disease/complications , Coronary Disease/pathology , Coronary Vessels/pathology , Crowding , Dwarfism/complications , Female , Male , SwineSubject(s)
Animals, Zoo , Arteriosclerosis/veterinary , Bird Diseases , Coronary Disease/veterinary , Social Environment , Animal Nutritional Physiological Phenomena , Animals , Arteriosclerosis/epidemiology , Arteriosclerosis/metabolism , Behavior, Animal , Bird Diseases/epidemiology , Bird Diseases/metabolism , Birds , Coronary Disease/epidemiology , Coronary Disease/metabolism , Female , Haplorhini , Male , Myocardial Infarction/epidemiology , Myocardial Infarction/metabolism , Myocardial Infarction/veterinary , PennsylvaniaSubject(s)
Arteriosclerosis/veterinary , Disease Models, Animal , Swine Diseases/pathology , Animals , Aorta/pathology , Arteries/pathology , Arteriosclerosis/metabolism , Arteriosclerosis/pathology , Cell Division , Cerebral Arteries/pathology , Cholesterol/blood , Cholesterol/metabolism , Collagen , Coronary Vessels/pathology , Glycosaminoglycans/metabolism , Rabbits , Rats , SwineSubject(s)
Arteriosclerosis/etiology , Behavior, Animal , Stress, Psychological , Animals , Aorta/pathology , Arteriosclerosis/pathology , Coronary Vessels/pathology , Female , Glomerulonephritis/pathology , Humans , Kidney/pathology , Male , Mice , Mice, Inbred Strains , Myocardium/pathology , Nephritis, Interstitial/pathologyABSTRACT
CORONARY, AORTIC AND INTERCRANIAL ATHEROSCLEROSIS HAS BEEN COMPARED IN SWINE MAINTAINED UNDER THE FOLLOWING CONDITIONS: (1) adequate food and housing but animals held in test social situations for 1 year; postmortem examination at ages of 13 to 15 months; (2) food and management designed for high productivity; postmortem examination at ages of 6 to 9 years; (3) an outdoor system of husbandry and a cooked garbage diet; postmortem examination at ages of 8 to 14 years.Extramural coronary, aortic and intracranial atherosclerosis was most advanced in swine that were fed garbage. Cerebral infarction (cerebromalacia) also was most advanced in these swine but developed in swine of the younger groups in which it was associated with atherosclerosis of small intracranial extracerebral arteries rather than with stenosis of the larger intracranial extracerebral arteries as in the oldest swine. The lesions of atherosclerosis in swine of these 3 age-groups form a continuous series and are morphologically identical with corresponding stages of atherosclerosis of man.It is concluded that swine can replace non-human primates as subjects for studies of atherosclerotic vascular disease, and that experimental designs must allow for age and behaviour patterns of the species.
