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1.
Tuberculosis (Edinb) ; 125: 101995, 2020 12.
Article in English | MEDLINE | ID: mdl-32979676

ABSTRACT

The Mycobacterium tuberculosis complex (MTC) has affected South American populations since ca. 200 years BCE. In Argentina, possible cases date from ca. 1000-1400 Common Era (CE). This paper describes the oldest (905-1030 CE) confirmed case of tuberculosis (TB) in a young adult male from Lomitas de Saujil (Tinogasta, Catamarca, Argentina). Osteolytic lesions on the bodies of the lower spine were macroscopically and radiographically identified. Bilateral new bone formation was seen on the visceral vertebral third of several ribs and in long bones, compatible with hypertrophic osteoarthropathy. Representative rib and hand bones gave profiles for MTC-specific C27-C32 mycocerosic acid lipid biomarkers; these were strongest in one heavily-lesioned lower rib, which also had MTC-diagnostic C76-C89 mycolic acids and positive amplification of MTC-typical IS6110 aDNA fragments. During the first millennium CE, the intense social interaction, the spatial circumscription of villages among the pre-Hispanic societies in the mesothermal valleys of Catamarca and the fluid contacts with the Eastern lowlands, valleys and puna, were factors likely to favor disease transmission. It is proposed that TB arrived from northern Chile and dispersed towards the northeast into the Yocavil valley, where several cases of TB infection were macroscopically identified for a later chronology.


Subject(s)
Bone and Bones/diagnostic imaging , DNA, Bacterial/history , Mycobacterium tuberculosis/genetics , Paleopathology/methods , Tuberculosis, Osteoarticular/history , Adult , Argentina/epidemiology , Bone and Bones/microbiology , DNA, Bacterial/analysis , History, 15th Century , History, 16th Century , History, Ancient , History, Medieval , Humans , Incidence , Male , Mycobacterium tuberculosis/isolation & purification , Tuberculosis, Osteoarticular/diagnosis , Tuberculosis, Osteoarticular/epidemiology
2.
Proc Biol Sci ; 274(1609): 545-54, 2007 Feb 22.
Article in English | MEDLINE | ID: mdl-17476775

ABSTRACT

Archaeological maize specimens from Andean sites of southern South America, dating from 400 to 1400 years before present, were tested for the presence of ancient DNA and three microsatellite loci were typed in the specimens that gave positive results. Genotypes were also obtained for 146 individuals corresponding to modern landraces currently cultivated in the same areas and for 21 plants from Argentinian lowland races. Sequence analysis of cloned ancient DNA products revealed a high incidence of substitutions appearing in only one clone, with transitions prevalent. In the archaeological specimens, there was no evidence of polymorphism at any one of the three microsatellite loci: each exhibited a single allelic variant, identical to the most frequent allele found in contemporary populations belonging to races Amarillo Chico, Amarillo Grande, Blanco and Altiplano. Affiliation between ancient specimens and a set of races from the Andean complex was further supported by assignment tests. The striking genetic uniformity displayed by the ancient specimens and their close relationship with the Andean complex suggest that the latter gene pool has predominated in the western regions of southern South America for at least the past 1400 years. The results support hypotheses suggesting that maize cultivation initially spread into South America via a highland route, rather than through the lowlands.


Subject(s)
Crops, Agricultural/genetics , Microsatellite Repeats , Zea mays/genetics , Crops, Agricultural/classification , Genotype , Geography , Phylogeny , Polymorphism, Genetic , Sequence Analysis, DNA , South America , Zea mays/classification
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