ABSTRACT
A 70-year-old male with regionally recurrent Merkel cell cancer obtained a complete remission with three cycles of VP16 and cisplatin. His response was consolidated with local radiation therapy. Two additional patients have been reported to have responded to the same combination. Chemotherapy consisting of either cyclophosphamide, vincristine, and doxorubicin or VP16 and cisplatin should be considered in locally recurrent Merkel cell cancer.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Merkel Cell/drug therapy , Skin Neoplasms/drug therapy , Aged , Cisplatin/administration & dosage , Combined Modality Therapy , Etoposide/administration & dosage , Humans , Male , Remission InductionSubject(s)
Dermatomycoses/drug therapy , Ketoconazole/therapeutic use , Female , Humans , Ketoconazole/adverse effects , MaleSubject(s)
Polyarteritis Nodosa/complications , Uveitis/complications , Aged , Female , Humans , Skin/pathologySubject(s)
Methoxsalen/adverse effects , Nails , Photosensitivity Disorders/chemically induced , Adult , Female , Humans , Skin Diseases/etiologyABSTRACT
Oriental sore (acute cutaneous leishmaniasis) is usually a self-limited infection of the skin caused by the protozoan Leishmania tropica. This disease is endemic to the Mediterranean, Asia, Africa, and the Middle East, and is seen in this country among travellers and immigrants. We found four cases at the University of Michigan and diagnosed and treated the disorder. Some of the treatments currently recommended for this disease are potentially toxic, and none have been proved to be of real value. Uncomplicated, acute cutaneous leishmaniasis (L tropica) may best be managed by withholding treatment and observing the patient.
