ABSTRACT
The aim of study was the evaluation of tissue plasminogen activator (t-PA) and its inhibitor (PAI-1) in the II type diabetes on the base of the common fibrinolytic system tests as euglobulin lysis time (ELT) and the concentration of fibrin/fibrinogen products (FDP). The studies were performed in 21 outpatients suffering of II type diabetes aged 38-65 (median 56.0) years treated with diet and sulphonylcarbamide derivates. The control group contained 18 healthy persons aged 33-65 (median 42.0) years. In the blood the following determinations were performed: antigen of t-PA and PAI-1, ELT and FDP. In the blood of patients with II type diabetes increased. t-PA Ag and PAI-1 Ag concentrations were observed.
Subject(s)
Diabetes Mellitus, Type 2/physiopathology , Plasminogen Inactivators/physiology , Tissue Plasminogen Activator/physiology , Adult , Aged , Fibrinolysis/physiology , Humans , Middle AgedABSTRACT
Uric acid-a potent endogenous antioxidant-may play a certain role in some eye diseases. However, its content in intraocular humors has not been examined so far. Samples of aqueous and vitreous humor were collected from 32 dead persons for examination. Uric acid was marked by indirect method with uricase. Uric acid level in aqueous humor ranges from 166.67 to 446.4 mumol/l (mean 309.34), whereas in vitreous humor from 77.38 to 452.00 mumol/l (mean 220.80).
Subject(s)
Aqueous Humor/chemistry , Uric Acid/analysis , Vitreous Body/chemistry , Female , Humans , Male , Reference ValuesABSTRACT
Aqueous humor was taken from 32 patients with senile and presenile cataract at the operation by means of anterior chamber puncture. Uric acid was marked by indirect method with uricase. The mean content of uric acid in aqueous humor of patients with cataract was 187.13 mumol/l and in the control group 309.34 mumol/l. The difference between the groups is statistically significant. The results suggest that uric acid as strong endogenous antioxidant may play an important role in pathogenesis of cataract.
Subject(s)
Aqueous Humor/chemistry , Cataract/metabolism , Uric Acid/analysis , Adult , Aged , Aged, 80 and over , Cataract/etiology , Female , Humans , Male , Middle AgedABSTRACT
Uric acid--a potent endogenous antioxidant--may play a certain role in some eye diseases. However, its content in intraocular humors has not been examined so far. Samples of aqueous and vitreous humor were collected from 32 dead persons for examination. Uric acid was marked by indirect method with uricase. Uric acid level in aqueous humor ranges from 166.67 to 446.4 mumol/l (mean 309.34), whereas in vitreous humor from 77.38 to 452.00 mumol/l (mean 220.80).
Subject(s)
Aqueous Humor/chemistry , Uric Acid/analysis , Vitreous Body/chemistry , Female , Humans , Male , Postmortem Changes , Reference ValuesABSTRACT
Aqueous humor was taken from 32 patients with senile and presenile cataract at the operation by means of anterior chamber puncture. Uric acid was marked by indirect method with uricase. The mean content of uric acid in aqueous humor of patients with cataract was 187.13 mumol/l and in the control group 309.34 mumol/l. The difference between the groups is statistically significant. The results suggest that uric acid as strong endogenous antioxidant may play an important role in pathogenesis of cataract.
