ABSTRACT
A 68-year-old man was hospitalised with a vascular occlusion in the left leg. After treatment with urokinase he developed multiple intracerebral haemorrhages. The occlusion and the intracerebral haemorrhages evoked by urokinase were caused by embolisation originating from a cardiac metastasis of a renal-cell carcinoma. Cardiac surgery was performed, but complete removal of the tumour was not possible. The process of embolisation continued and the patient died a few weeks after diagnosis. Cardiac metastasis is seen in 10% of all cancer patients. Most of these metastases remain without symptoms. Left ventricular metastasis of renal-cell carcinoma without involvement of the inferior V. cava is very rare. If embolic occlusion of one or more vascular areas is present, transthoracic echography of the heart should be performed. Early detection and surgical treatment prevent further embolisation which may result in a better prognosis.
Subject(s)
Carcinoma, Renal Cell/secondary , Cerebral Hemorrhage/etiology , Heart Neoplasms/secondary , Intracranial Embolism/etiology , Kidney Neoplasms/pathology , Aged , Carcinoma, Renal Cell/complications , Carcinoma, Renal Cell/surgery , Fatal Outcome , Fibrinolytic Agents/adverse effects , Fibrinolytic Agents/therapeutic use , Heart Neoplasms/complications , Heart Neoplasms/surgery , Humans , Male , Prognosis , Urokinase-Type Plasminogen Activator/adverse effects , Urokinase-Type Plasminogen Activator/therapeutic useSubject(s)
Brain Infarction/etiology , Cerebellum/blood supply , Deafness/etiology , Functional Laterality , Vertebral Artery Dissection/complications , Vertebral Artery Dissection/diagnosis , Acute Disease , Adult , Brain Infarction/diagnosis , Brain Infarction/physiopathology , Cerebellum/pathology , Diagnosis, Differential , Female , Humans , Magnetic Resonance Imaging , Neck Pain/etiology , Neurologic Examination , Vertigo/etiologyABSTRACT
Here, we show that amyloid-beta (Abeta) is capable to prime and activate the respiratory burst of human macrophages. Previously, the N-terminus of Abeta(1-42) has been shown to contain a cell binding domain that is implicated in eliciting neuropathogenic microglia in vitro. To evaluate the role of this domain in the Abeta(1-42)-induced respiratory burst activity, the effect of Abeta subfragments on the Abeta(1-42)-induced superoxide release were studied. On the basis of the antagonistic properties of Abeta(1-16), it is concluded that the N-terminal region of Abeta is critical for the cellular binding and consequent activation of the respiratory burst of human phagocytes.
Subject(s)
Amyloid beta-Peptides/chemistry , Amyloid beta-Peptides/pharmacology , Macrophages/immunology , Macrophages/metabolism , Peptide Fragments/chemistry , Peptide Fragments/pharmacology , Respiratory Burst/immunology , Alzheimer Disease/immunology , Alzheimer Disease/metabolism , Amyloid beta-Peptides/metabolism , Binding, Competitive/drug effects , Binding, Competitive/immunology , Brain Chemistry/immunology , Flow Cytometry , Fluorescein-5-isothiocyanate , Fluorescent Dyes , Humans , Luminescent Measurements , Macrophages/chemistry , Monocytes/chemistry , Monocytes/immunology , Monocytes/metabolism , Peptide Fragments/metabolism , Protein Binding/immunology , Respiratory Burst/drug effects , Superoxides/metabolismABSTRACT
Cerebral metastasis occur in 10 to 20% of patients with choriocarcinoma. We describe the twelfth patient with oncotic aneurysms from choriocarcinoma verified by cerebral angiography. The importance to consider this disease in a woman of childbearing age who develop an intracerebral hemorrhage or a lesion with mass effect is emphasized, as well as laboratial and radiological characteristics. Therapeutic approaches with chemotherapic agents, surgery and irradiation are discussed.
Subject(s)
Brain Neoplasms/secondary , Choriocarcinoma/secondary , Intracranial Aneurysm/etiology , Uterine Neoplasms/pathology , Adult , Brain Neoplasms/complications , Brain Neoplasms/diagnostic imaging , Cerebral Angiography , Cerebral Hemorrhage/diagnostic imaging , Cerebral Hemorrhage/etiology , Choriocarcinoma/complications , Choriocarcinoma/diagnostic imaging , Female , Humans , Intracranial Aneurysm/diagnostic imaging , Tomography, X-Ray ComputedABSTRACT
Cerebral metastasis occur in 10 to 20% of patients with choriocarcinoma. We describe the twelfth patient with oncotic aneurysms from choriocarcinoma verified by cerebral angiography. The importance to consider this disease in a woman of childbearing age who develop an intracerebral hemorrhage or a lesion with mass effect is emphasized, as well as laboratial and radiological characteristics. Therapeutic approaches with chemotherapic agents, surgery and irradiation are discussed
Subject(s)
Humans , Female , Adult , Brain Neoplasms , Choriocarcinoma , Intracranial Aneurysm , Uterine Neoplasms , Brain Neoplasms , Cerebral Angiography , Cerebral Hemorrhage , Choriocarcinoma , Intracranial Aneurysm , Tomography, X-Ray ComputedABSTRACT
In order to obtain frames of reference to determine the place of intersection of the carotid siphon with the dura mater in conventional arteriograms, a debated topic lacking general agreement in the literature, 34 cadaveric sphenoids were prepared with the injection of radiopaque medium in both internal carotid arteries. After having marked the dura mater with steel wire, the pieces were radiographed in lateral view. The points of intersection of the clinoclinoid line and the sphenoidal line with the internal carotid artery as well as the emergence of the ophthalmic artery and its posterior projection were marked on the radiographs obtained. The distances between the various points were measured and submitted to statistical treatment. The results showed multiple regressions with a strong correlation coefficient in two equations. A table was built in which, knowing the distances between the points of the clinoclinoid and the sphenoidal plane lines and those of the ophthalmic artery and its projection, the position of the dura mater which covers the cavernous sinus may be estimated in arteriograms.
