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1.
Pediatr Obes ; 12 Suppl 1: 26-37, 2017 08.
Article in English | MEDLINE | ID: mdl-27378525

ABSTRACT

BACKGROUND: Maternal diet during pregnancy may contribute to the risk of offspring adiposity. OBJECTIVES: The objective of the study is to explore the associations between maternal antenatal dietary fatty acid intake and the risk of offspring overweight and obesity at the ages of 2 to 7 years. METHODS: In a prospective Finnish birth cohort with 3807 mother-child pairs, maternal diet in late pregnancy was assessed with a food frequency questionnaire. Intakes of total fatty acids and individual saturated, monounsaturated and polyunsaturated fatty acids (PUFAs) were calculated. Generalized estimating equation models were used to study the associations of maternal dietary variables with repeatedly measured offspring overweight and obesity. RESULTS: In girls, maternal intake ratio of n-6:n-3 PUFAs had a U-shaped association with obesity (adjusted OR for the lowest 2.0 [95% CI 1.27-3.20] and the highest 1.7 [1.03-2.73] vs. the two middle quartiles of n-6:n-3 PUFAs, p = 0.01). In boys, arachidonic acid (20:4n-6): docosahexaenoic acid + eicosapentaenoic acid ratio was associated with obesity (adjusted OR for the lowest 1.0 [0.60-1.57] and the highest 0.5 [0.26-0.88] vs. the two middle quartiles, p = 0.02). Saturated fatty acids and monounsaturated fatty acids were not associated with overweight or obesity in either sex. CONCLUSIONS: Maternal intakes of PUFAs in late pregnancy were associated with risk of later obesity differently in girls and boys.


Subject(s)
Adiposity/physiology , Fatty Acids/administration & dosage , Overweight/etiology , Pediatric Obesity/etiology , Anthropometry , Child , Child, Preschool , Cohort Studies , Diet , Fatty Acids/adverse effects , Feeding Behavior , Female , Finland , Humans , Male , Mothers , Overweight/epidemiology , Pediatric Obesity/epidemiology , Pregnancy , Prospective Studies , Risk Assessment , Surveys and Questionnaires
2.
Acta Diabetol ; 52(4): 763-72, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25563476

ABSTRACT

AIMS: We examined maternal dietary intake of fatty acids and foods which are sources of fatty acids during lactation and whether they are associated with the risk of preclinical and clinical type 1 diabetes in the offspring. METHODS: The subjects comprised a cohort of 2,939 mother-child pairs from the prospective Type 1 Diabetes Prediction and Prevention Study. Composition of maternal diet during the third month of lactation was assessed by a validated food frequency questionnaire. Among the children with HLA-conferred susceptibility to type 1 diabetes, 172 developed preclinical and 81 clinical diabetes. Average follow-up for preclinical type 1 diabetes was 7.5 years (range 0.2-14.0 years) and for clinical type 1 diabetes 7.7 years (0.2-14.0 years). RESULTS: Maternal intake of fatty acids during lactation was not associated with the risk of type 1 diabetes in the offspring. After adjusting for putative confounders, maternal total consumption of red meat and meat products during lactation was associated both with increased risk for preclinical [hazard ratio (HR) 1.19, 95 % CI 1.02-1.40, p = 0.038] and clinical type 1 diabetes (HR 1.27, 95 % CI 1.06-1.52, p = 0.025). In particular, consumption of processed meat products showed an association with increased risk for type 1 diabetes (HR 1.23, 95 % CI 1.02-1.48, p = 0.045). Maternal use of vegetable oils was associated with increased risk for preclinical type 1 diabetes (HR 1.21, 95 % CI 1.03-1.41, p = 0.023). CONCLUSIONS: Maternal consumption of red meat, especially processed meat, during lactation may increase the risk of type 1 diabetes.


Subject(s)
Diabetes Mellitus, Type 1/epidemiology , Diabetes Mellitus, Type 1/etiology , Eating/physiology , Fatty Acids/administration & dosage , Lactation/physiology , Maternal Nutritional Physiological Phenomena , Mother-Child Relations , Adolescent , Asymptomatic Diseases , Child , Child, Preschool , Cohort Studies , Diabetes Mellitus, Type 1/pathology , Diet , Feeding Behavior/physiology , Female , Food , Humans , Infant , Infant Nutritional Physiological Phenomena , Infant, Newborn , Male , Risk Factors
3.
J Evol Biol ; 22(7): 1545-55, 2009 Jul.
Article in English | MEDLINE | ID: mdl-19500204

ABSTRACT

We studied ecological divergence of host use ability in a generalist marine herbivore living in two distinct host plant assemblages. We collected Idotea balthica isopods from three populations dominated by the brown alga Fucus vesiculosus and three dominated by the seagrass Zostera marina. In two reciprocal common garden feeding experiments for adult and laboratory-born juvenile isopods, we found that isopods from both assemblages performed better with their sympatric dominant host species than did isopods allopatric to this host. This indicates parallel divergence of populations according to the sympatric host plant assemblage. Furthermore, initial body size and body size-dependent mortality differed between populations from the two assemblages. In nature, this may result in lower fitness of immigrants compared with that of residents and consequently reinforce divergence of the populations. Finally, we discuss how phenotypic plasticity and maternal and random effects may associate with the results.


Subject(s)
Ecosystem , Isopoda/genetics , Animals , Finland , Isopoda/classification , Phaeophyceae
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