ABSTRACT
The purpose of this study was to directly compare the efficacy of Tc-99m MIBI with TI-201/Tc-99m pertechnetate scintigraphy for localizing parathyroid adenomas in patients with primary hyperparathyroidism. Of 21 patients suspected of having primary hyperparathyroidism who had undergone both studies, 14 had subsequent surgery and pathologic correlation. Based on the surgical and pathologic results, Tc-99m MIBI yielded 13 true-positive and 1 false-negative result. Thallium-201/ Tc-99m pertechnetate imaging yielded eight true-positive, four false-negative, and two nondiagnostic studies because of lack of Tc-99m pertechnetate uptake from thyroid hormone suppression. In conclusion, Tc-99m MIBI scintigraphy is an accurate method for localizing parathyroid adenomas in patients with primary hyperparathyroidism and the results suggest that it is superior to using TI-201/Tc-99m pertechnetate.
Subject(s)
Hyperparathyroidism/diagnostic imaging , Radiopharmaceuticals , Sodium Pertechnetate Tc 99m , Technetium Tc 99m Sestamibi , Thallium Radioisotopes , Adenoma/diagnostic imaging , Adenoma/surgery , Adolescent , Adult , Aged , False Negative Reactions , Female , Humans , Hyperparathyroidism/drug therapy , Hyperparathyroidism/surgery , Image Enhancement , Injections, Intravenous , Male , Middle Aged , Parathyroid Neoplasms/diagnostic imaging , Parathyroid Neoplasms/surgery , Radionuclide Imaging , Radiopharmaceuticals/administration & dosage , Sensitivity and Specificity , Single-Blind Method , Sodium Pertechnetate Tc 99m/administration & dosage , Technetium Tc 99m Sestamibi/administration & dosage , Thallium Radioisotopes/administration & dosage , Thyroid Gland/diagnostic imaging , Thyroid Gland/drug effects , Thyroid Hormones/therapeutic useSubject(s)
Angioplasty, Balloon , Fibrinolytic Agents/therapeutic use , Leriche Syndrome/therapy , Administration, Oral , Fibrinolytic Agents/administration & dosage , Humans , Lipolysis/drug effects , Male , Middle Aged , Pentosan Sulfuric Polyester/administration & dosage , Pentosan Sulfuric Polyester/therapeutic useABSTRACT
A gastric tumor was found in a 64-year-old woman who later developed flushing, tachycardia, headache, and lacrymation. The plasma pancreatic polypeptide (PP) level was 700 times normal values, and the majority of the tumor cells were immunoreactive to PP antiserum. Symptoms were alleviated, and PP levels fell after embolization of the hepatic artery for liver metastases. This is the first reported case of gastric PP-producing endocrine tumor.
