ABSTRACT
The effect of nifedipine, a calcium antagonist on fasting blood glucose level, glucose tolerance, glucose-induced insulin and glucagon secretion was studied in healthy nondiabetic volunteers. Nifedipine 10mg twice daily for four weeks did not affect fasting blood glucose level, glucose tolerance, glucose-induced insulin and glucagon secretion.
Subject(s)
Blood Glucose , Nifedipine/pharmacology , Adult , Humans , MaleSubject(s)
Lipids/blood , Metronidazole/pharmacology , Nitroimidazoles/pharmacology , Tinidazole/pharmacology , Adult , Humans , MaleABSTRACT
The effects of the calcium antagonists verapamil and nifedipine on blood glucose levels, glucose tolerance, insulin secretion during glucose tolerance and hypoglycaemic effect of tolbutamide were studied in normal nondiabetic rabbits. Daily dosage of 40 mg/kg verapamil and 5 mg/kg nifedipine given orally up to 7 days did not affect blood glucose level, glucose tolerance, insulin secretion during glucose tolerance and hypoglycaemic activity of tolbutamide 250 mg/kg p.o.
Subject(s)
Blood Glucose/metabolism , Calcium Channel Blockers/pharmacology , Animals , Glucose Tolerance Test , Insulin/metabolism , Insulin Secretion , Male , Nifedipine/pharmacology , Rabbits , Tolbutamide/pharmacology , Verapamil/pharmacologyABSTRACT
Carbamazepine (CA) and sodium valproate (SV) were studied for their actions of central nervous system and neuromuscular junction. CA and SV given ip neither possessed analgesic nor hypothermic activity in rats, nor did they alter the pentobarbitone sleeping time in mice. The drug had no effect on the frog rectus muscle nor did they alter its responses to acetylcholine. Both CA and SV produced a dose related decrease in indirectly evoked contractions of rat diaphragm and cat gastrocnemius muscle without much altering the directly evoked responses. This effect may be due to their local anaesthetic property, which was observed in infiltration test in guinea pigs.
