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Bioorg Med Chem Lett
; 19(12): 3264-7, 2009 Jun 15.
Article
in English
| MEDLINE
| ID: mdl-19423347
ABSTRACT
An unnatural amino acid was synthesized to incorporate a quinone methide-generating activity-based probe for protein tyrosine phosphatases (PTPs) and then integrated into a PTP1B-specific substrate. The resulting probe led to preferential labeling of PTP1B in cell lysates in the presence of PTP4A3.