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Clin Exp Rheumatol ; 37 Suppl 117(2): 45-51, 2019.
Article in English | MEDLINE | ID: mdl-30789149

ABSTRACT

OBJECTIVES: Primary angiitis of the central nervous system (PACNS) is a vasculitis confined to the brain and spinal cord, which often presents with severe cognitive and functional deficits. Despite progress in diagnosis, little is still known about long-term outcomes. Our aim was to evaluate long-term functional capabilities, quality of life, and depression, and to determine the effect of treatment duration on patient outcomes. METHODS: We identified patients by ICD-9 codes for cerebral angiitis, and included them if they met two of the three following criteria: inflammatory cerebrospinal fluid (CSF), cerebral angiogram typical of vasculitis, or findings of vasculitis on pathologic examination of brain tissue. Disability was assessed by the Barthel Index, quality of life was assessed by EuroQol, and depression was assessed with Patient Health Questionnaire. RESULTS: Seventy-eight patients met the inclusion criteria, of which 27 responded to the questionnaire (34.6%). Mean follow-up of those who responded was 5.5 years (± 4.7). Nineteen of 27 patients (70.4%) had mild disability; meanwhile, 5 (18.5%) had severe disability. Fourteen of 27 patients (51.9%) had no mobility problem, 18 (66.7%) had no problems with self-care, 15 (55.6%) had no problems with usual activities, 14 (51.9%) had no pain, and 8 (29.6%) had no anxiety. Approximately 70% of patients had minimal or no depression. CONCLUSIONS: This is the longest reported follow-up of patients with PACNS described in the literature to date. Most patients had mild long-term disability and minimal to no depression, which may be reflective of treatment advances.


Subject(s)
Cognition Disorders/diagnosis , Depressive Disorder/diagnosis , Vasculitis, Central Nervous System , Cerebral Angiography , Cognition Disorders/etiology , Depressive Disorder/etiology , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neurologic Examination , Quality of Life , Vasculitis, Central Nervous System/cerebrospinal fluid , Vasculitis, Central Nervous System/complications , Vasculitis, Central Nervous System/diagnosis
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