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Eye (Lond) ; 26(7): 972-5, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22562189

ABSTRACT

PURPOSE: To determine whether the intraocular penetration of travoprost 0.004% is affected by central corneal thickness. METHODS: Sixty-four patients who were scheduled for cataract surgery without any other ophthalmologic pathology of significance were enrolled in this study. At 120 min before surgery, one drop of travoprost 0.004% was instilled in the eye to be operated on. At the start of surgery, a sample of aqueous humour was extracted to subsequently determine its AL-5848 concentration. These concentrations were compared among three groups of patients established according to central corneal thickness measurements obtained by ultrasound pachymetry. RESULTS: Mean AL-5848 concentrations were 3.27±2.03 ng/ml in Group I (CCT<511 microns), 3.27±2.44 ng/ml in Group II (CCT≥511 and ≤574 microns), and 2.73±2.15 ng/ml in Group III (CCT>574 microns), indicating no significant differences among the groups. CONCLUSIONS: We were unable to demonstrate the greater or lesser penetration of travoprost depending on corneal thickness, which could explain differences in patient responses to this drug.


Subject(s)
Antihypertensive Agents/pharmacokinetics , Aqueous Humor/metabolism , Cloprostenol/analogs & derivatives , Cornea/anatomy & histology , Glaucoma/metabolism , Adult , Antihypertensive Agents/therapeutic use , Cloprostenol/pharmacokinetics , Cloprostenol/therapeutic use , Cornea/metabolism , Female , Glaucoma/drug therapy , Humans , Male , Travoprost
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