[Platelet aggregation and the fibronectin level of the blood in children with chronic glomerulonephritis]. / Agregatsiia trombotsitov i uroven' fibronektina v krovi u detei s khronicheskim glomerulonefritom.

We compared platelet aggregation with changes in fibronectin (FN) plasma levels in children with various forms of primary CGN. We found that a rise in platelet aggregation and plasma FN level depends on CGN clinical form, extent of inflammation and sclerotic changes in nephric tissue. The greatest changes occurred in patients with nephrotic CGN and with segmentary glomerulosclerosis.

[Fibronectin levels in blood, urine and kidney in children with kidney diseases]. / Soderzhanie fibronektina v krovi, moche i pochechnoi tkani pri bolezniakh pochek u detei.

The level of plasma fibronectin (FN) is increasing in prognostically unfavourable morphological forms of childrens glomerulonephritis being in direct relationship with the activity index and sclerosis index. Urine FN excretion depends upon generalization of the tubulointerstitial changes, presence in the kidney of synechia and segmentary sclerosis of the glomeruli capillaries. A direct correlation is established between FN in the renal tissue and the degree of the mesangial cell proliferation and the spread of sclerotic changes.