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1.
AJNR Am J Neuroradiol ; 35(1): 170-5, 2014 Jan.
Article in English | MEDLINE | ID: mdl-23868150

ABSTRACT

BACKGROUND AND PURPOSE: DWI has been increasingly used to characterize orbital masses and provides quantitative information in the form of the ADC, but studies of DWI of orbital masses have shown a range of reported sensitivities, specificities, and optimal threshold ADC values for distinguishing benign from malignant lesions. Our goal was to determine the optimal use of DWI for imaging orbital masses through aggregation of data from multiple centers. MATERIALS AND METHODS: Source data from 3 previous studies of orbital mass DWI were aggregated, and additional published data points were gathered. Receiver operating characteristic analysis was performed to determine the sensitivity, specificity, and optimal ADC thresholds for distinguishing benign from malignant masses. RESULTS: There was no single ADC threshold that characterized orbital masses as benign or malignant with high sensitivity and specificity. An ADC of less than 0.93 × 10(-3) mm(2)/s was more than 90% specific for malignancy, and an ADC of less than 1.35 × 10(-3) mm(2)/s was more than 90% sensitive for malignancy. With these 2 thresholds, 33% of this cohort could be characterized as "likely malignant," 29% as "likely benign," and 38% as "indeterminate." CONCLUSIONS: No single ADC threshold is highly sensitive and specific for characterizing orbital masses as benign or malignant. If we used 2 thresholds to divide these lesions into 3 categories, however, a majority of orbital masses can be characterized with >90% confidence.


Subject(s)
Diffusion Magnetic Resonance Imaging/methods , Image Interpretation, Computer-Assisted/methods , Models, Statistical , Orbital Neoplasms/pathology , Statistics as Topic , Computer Simulation , Female , Humans , Male , Reproducibility of Results , Sensitivity and Specificity
2.
Cancer Imaging ; 12: 452-63, 2012 Oct 26.
Article in English | MEDLINE | ID: mdl-23108223

ABSTRACT

This review provides an overview of the current status of the published data on diffusion magnetic resonance (MR) imaging of chest tumors. Diffusion MR imaging is a non-invasive imaging technique that measures the differences in water mobility in different tissue microstructures and quantifies them based on the apparent diffusion coefficient. Diffusion MR imaging has been used for the characterization, grading and staging of lung cancer as well as for differentiating central tumors from post-obstructive consolidation. In addition, this technique helps in differentiating malignant from benign pulmonary and mediastinal tumors as well as in the characterization of pleural mesothelioma and effusion. Diffusion MR imaging can be incorporated into routine morphological MR imaging to improve radiologist confidence in image interpretation and to provide functional assessments of chest tumors during the same examination. Diffusion MR imaging could be used in the future as a functional imaging technique for tumors of the chest.


Subject(s)
Diffusion Magnetic Resonance Imaging/methods , Thoracic Neoplasms/diagnosis , Diagnosis, Differential , Humans , Reproducibility of Results
3.
AJNR Am J Neuroradiol ; 30(3): 444-52, 2009 Mar.
Article in English | MEDLINE | ID: mdl-19095789

ABSTRACT

Our aim was to review the imaging findings of relatively common lesions involving the cavernous sinus (CS), such as neoplastic, inflammatory, and vascular ones. The most common are neurogenic tumors and cavernoma. Tumors of the nasopharynx, skull base, and sphenoid sinus may extend to the CS as can perineural and hematogenous metastases. Inflammatory, infective, and granulomatous lesions show linear or nodular enhancement of the meninges of the CS but often have nonspecific MR imaging features. In many of these cases, involvement elsewhere suggests the diagnosis. MR imaging is sensitive for detecting vascular lesions such as carotid cavernous fistulas, aneurysms, and thromboses.


Subject(s)
Brain Neoplasms/pathology , Cavernous Sinus/pathology , Infections/pathology , Magnetic Resonance Imaging , Vascular Diseases/pathology , Humans
4.
Acta Radiol ; 49(3): 364-70, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18365828

ABSTRACT

BACKGROUND: Differentiation between the viable and necrotic parts of a tumor is essential for accurate biopsy results and for treatment planning. PURPOSE: To determine the role of diffusion-weighted magnetic resonance (MR) imaging in differentiation between the viable and necrotic parts of head and neck tumors. MATERIAL AND METHODS: Thirty patients with malignant head and neck tumors underwent postcontrast MR imaging. Diffusion MR imaging was done on a 1.5T unit using multislice single-shot echo-planar imaging. Diffusion-weighted MR images were acquired with a diffusion-weighted factor b of 0, 500, and 1000 s/mm(2), and an apparent diffusion coefficient (ADC) map was reconstructed. The ADC value was measured within the enhanced and nonenhanced part of the tumor, and the mean ADC values were calculated. The ADC value was correlated with biopsy results. RESULTS: The mean ADC value of a viable part of the tumor was 1.17+/-0.33 x 10(-3) mm(2)/s, and of the necrotic parts of the tumor 2.11+/-0.05 x 10(-3) mm(2)/s. The difference in the ADC value between the viable and necrotic parts of the head and neck tumors was statistically significant (P<0.001). Sensitivity, specificity, and accuracy of the ADC value were 92.9%, 93%, and 94.6%, respectively. CONCLUSION: Creation of an ADC map is an excellent method for differentiation between the viable and necrotic parts of head and neck tumors. Thus, the ADC map can be used to select the best biopsy site and to detect tumor viability in post-treatment follow-up of patients after radiation therapy.


Subject(s)
Diffusion Magnetic Resonance Imaging/methods , Echo-Planar Imaging/methods , Head and Neck Neoplasms/diagnosis , Adolescent , Adult , Aged , Contrast Media/administration & dosage , Diagnosis, Differential , Female , Gadolinium DTPA , Head/pathology , Head and Neck Neoplasms/pathology , Humans , Image Enhancement/methods , Male , Middle Aged , Neck/pathology , Necrosis , Predictive Value of Tests , Prospective Studies , Reproducibility of Results , Sensitivity and Specificity
5.
AJNR Am J Neuroradiol ; 29(3): 563-8, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18039755

ABSTRACT

BACKGROUND AND PURPOSE: Accurate imaging characterization of a solitary thyroid nodule has been clearly problematic. The purpose of this study was to evaluate the role of the apparent diffusion coefficient (ADC) values in the differentiation between malignant and benign solitary thyroid nodules. MATERIALS AND METHODS: A prospective study was conducted in 67 consecutive patients with solitary thyroid nodules who underwent diffusion MR imaging of the thyroid gland. Diffusion-weighted MR images were acquired with b factors of 0, 250, and 500 s/mm(2) by using single-shot echo-planar imaging. ADC maps were reconstructed. The ADC values of the solitary thyroid nodules were calculated and correlated with the results of histopathologic examination. Statistical analysis was performed. RESULTS: The mean ADC value of malignant solitary thyroid nodules was 0.73 +/- 0.19 x 10(-3) mm(2)/s and of benign nodules was 1.8 +/- 0.27 x 10(-3) mm(2)/s. The mean ADC values of malignant nodules were significantly lower than those of benign ones (P = .0001). There were no significant differences between the mean ADC values of various malignant thyroid nodules, but there were significant differences between the subtypes of benign thyroid nodules (P = .0001). An ADC value of 0.98 x 10(-3) mm(2)/s was proved as a cutoff value differentiating between benign and malignant nodules, with 97.5%, 91.7%, and 98.9% sensitivity, specificity, and accuracy, respectively. CONCLUSION: The ADC value is a new promising noninvasive imaging approach used for differentiating malignant from benign solitary thyroid nodules.


Subject(s)
Diffusion Magnetic Resonance Imaging/methods , Image Interpretation, Computer-Assisted/methods , Thyroid Nodule/diagnosis , Adult , Aged , Diagnosis, Differential , Female , Humans , Male , Middle Aged , Reproducibility of Results , Sensitivity and Specificity
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