ABSTRACT
A total of 132 patients with generalized sarcoidosis (GS) who amounted to 2.8% out of 4700 examinees and followed-up patients with respiratory sarcoidosis were studied. The pathomorphological study of biopsy specimens, X-ray functional, and immunological studies are of great importance in the diagnosis of GS. The latter in the examinees was characterized by the most common lesions to the skin, subcutaneous fat, peripheral lymph nodes, liver, spleen, central and peripheral nervous systems and eyes. The combined pathogenetic therapy developed, which involves corticosteroidal hormones and anabolic drugs, immunomodulators, antioxidants and antihypoxants has been shown to be effective in 62% of the patients.
Subject(s)
Lymphatic Diseases/diagnosis , Lymphatic Diseases/drug therapy , Sarcoidosis, Pulmonary/diagnosis , Sarcoidosis, Pulmonary/drug therapy , Adolescent , Adult , Aged , Drug Therapy, Combination , Eye Diseases/diagnosis , Eye Diseases/drug therapy , Eye Diseases/immunology , Female , Follow-Up Studies , Humans , Liver Diseases/diagnosis , Liver Diseases/drug therapy , Liver Diseases/immunology , Lymphatic Diseases/complications , Lymphatic Diseases/immunology , Male , Middle Aged , Peripheral Nervous System Diseases/diagnosis , Peripheral Nervous System Diseases/drug therapy , Peripheral Nervous System Diseases/immunology , Sarcoidosis/diagnosis , Sarcoidosis/drug therapy , Sarcoidosis/immunology , Sarcoidosis, Pulmonary/complications , Sarcoidosis, Pulmonary/immunology , Skin Diseases/diagnosis , Skin Diseases/drug therapy , Skin Diseases/immunology , Splenic Diseases/diagnosis , Splenic Diseases/drug therapy , Splenic Diseases/immunologyABSTRACT
Polyfepan, an enterosorbent, was used in the treatment of 96 dermatologic patients. The treatment proved to be effective in those with toxicoderma, secondary xanthomatosis, porphyria cutanea tarda, skin itching, and urticaria, particularly in the cases when toxic exposures and gastrointestinal conditions contributed to the disease pathogenesis. Polyfepan enterosorption is harmless, well-tolerated, and simple.
Subject(s)
Enterosorption , Lignin/therapeutic use , Skin Diseases/therapy , Combined Modality Therapy , Drug Evaluation , Humans , Time FactorsABSTRACT
A short-term cultivation of human skin combined with histoautoradiography have demonstrated that the blood serum of psoriasis patients is characterized by an in vitro effect similar to the beta-blocker effect, i.e. eliminates the epidermal chalone action, thus enhancing the epidermal cell proliferation in foci of skin involvement in psoriasis.
Subject(s)
Adrenergic beta-Antagonists , Psoriasis/blood , Adrenergic beta-Antagonists/pharmacology , Autoradiography , Growth Inhibitors/antagonists & inhibitors , Humans , Organ Culture Techniques , Receptors, Adrenergic, beta/drug effects , Skin/drug effectsABSTRACT
Six patients suffering from Pinkus' eosinophilic granuloma of the face are described. The etiology and pathogenesis of this disease are unknown, it is resistant to whatever conservative therapy. The authors suggest an effective method of laser destruction of the foci of skin involvement, giving a good stable cosmetic result.
Subject(s)
Eosinophilic Granuloma/surgery , Facial Dermatoses/surgery , Laser Therapy/methods , Adult , Chronic Disease , Follow-Up Studies , Humans , Male , Middle AgedABSTRACT
Two patients with Miescher's cheilitis are described, with different disease length and histologic picture in involved foci. The essence of granulomatous cheilitis is still to be found, this being confirmed by the literature reviewed by the authors. Further accumulation of thoroughly verified data is necessary to solve this problem.
Subject(s)
Melkersson-Rosenthal Syndrome/diagnosis , Adult , Biopsy , Epithelium/pathology , Female , Humans , Lip/pathology , Male , Melkersson-Rosenthal Syndrome/pathologySubject(s)
Scleroderma, Localized/diagnosis , Scleroderma, Systemic/diagnosis , Adult , Female , Humans , Infant, Newborn , Male , Middle AgedSubject(s)
Skin Diseases/physiopathology , Skin/physiopathology , Touch/physiology , Adult , Humans , Middle AgedSubject(s)
Hemoperfusion/methods , Intestinal Absorption , Lymphoma/therapy , Skin Neoplasms/therapy , Adsorption , Adult , Aged , Aged, 80 and over , Combined Modality Therapy , Female , Humans , Lignin/therapeutic use , Male , Methods , Middle AgedABSTRACT
Results of electron microscopic and cytophotometric studies of biopsy material from lymph nodes of patients with cutaneous lymphomas with low degree of malignancy are discussed, with special reference to early diagnostic criteria of the disease. Specific characteristics of tumor tissue involve the presence of atypical lymphocytes with marginal condensed chromatin extrusions of nuclear material, deep invaginations of the nuclear membrane, nuclear pockets, excess of the mean DNA content per nucleus above the diploid standard level, more than 5% of nuclei being in the hyperdiploid area. Electron microscopic and cytophotometric methods allowed to diagnose the tumor injury of lymph nodes, when the traditional histological techniques revealed no signs of malignancy.
