ABSTRACT
The effect of short term bromocriptine (5 mg/day, 5 days) on plasma epinephrine (E), norepinephrine (NE), dopamine (DA) and prolactin (PRL) was studied in 4 normal women and 6 bearing PRL-secreting tumors. When studied on placebo no significant differences were found between controls and patients in E, NE and DA plasma levels. Bromocriptine induced: a 70% decrease in PRL levels in both groups, a significant (p less than 0.05) decrease in plasma NE levels in the control group, no significant change in plasma NE levels in the hyperprolactinemic patients when considered as a group. These results do not indicate that bromocriptine is a useful tool in the diagnosis of defective central dopaminergic regulation since individual responses of the PRL-secreting tumor patients were variable. Nevertheless, the impaired response of the group as a whole may be suggesting an underlying alteration of DA2 receptor activity in these tumor patients.
Subject(s)
Bromocriptine/pharmacology , Catecholamines/blood , Pituitary Neoplasms/metabolism , Prolactin/metabolism , Adolescent , Adult , Dopamine/blood , Epinephrine/blood , Female , Humans , Norepinephrine/blood , Prolactin/blood , Receptors, Dopamine/physiologyABSTRACT
Comunicaron los autores el presente caso por su carácter excepcional - primera referencia sobre el tema en la literatura médica argentina - destacando su importancia ya que la rara incidencia de esta entidad nosológica ha ocasionado omisiones diagnósticas que pueden superarse (AU)
Subject(s)
Adult , Humans , Male , Encephalocele/physiopathologyABSTRACT
Comunicaron los autores el presente caso por su carácter excepcional - primera referencia sobre el tema en la literatura médica argentina - destacando su importancia ya que la rara incidencia de esta entidad nosológica ha ocasionado omisiones diagnósticas que pueden superarse
Subject(s)
Adult , Humans , Male , Encephalocele/physiopathologyABSTRACT
Se presenta la evolución de un niño (desde los 2 a los 9 años de edad) portador de un síndrome de Prader-Willi (hipotonía, hipogonadismo, retraso mental y obesidad). Presentó además ausencia de testículos en las bolsas, rubicundez de dorso de manos e hipotiroidismo. Fue tratado con opoterapia tiroidea con discreta mejoria clínica. En la actualidad persiste la obesidade de muy difícil resolución y la ectopia testicular, cuya cirugía no es aconsejable por el momento
Subject(s)
Humans , Male , Prader-Willi Syndrome/physiopathologyABSTRACT
Se presenta la evolución de un niño (desde los 2 a los 9 años de edad) portador de un síndrome de Prader-Willi (hipotonía, hipogonadismo, retraso mental y obesidad). Presentó además ausencia de testículos en las bolsas, rubicundez de dorso de manos e hipotiroidismo. Fue tratado con opoterapia tiroidea con discreta mejoria clínica. En la actualidad persiste la obesidade de muy difícil resolución y la ectopia testicular, cuya cirugía no es aconsejable por el momento (AU)
Subject(s)
Humans , Male , Prader-Willi Syndrome/physiopathologyABSTRACT
In diabetics with the anhidrotic syndrome, autonomic nerve fibres were studied in skin biopsies using argentic techniques and light microscopy. The Minor test was used to differentiate normal from anhidrotic skin areas. In the anhidrotic areas, histology of the nerve fibres showed beading, spindle-shaped thickening and fragmentation adjacent to the sweat glands. These changes were similar to those observed in two patients who had previously undergone lumbar sympathectomy. No abnormalities of the sympathetic nerve endings could be found in biopsies taken from normal areas of the forearm of the same patients. We conclude that the diabetic anhidrotic syndrome, a form of diabetic autonomic neuropathy, is due to a lesion of the sympathetic nerve supply to the skin. It is suggested that the Minor test or a skin biopsy should be performed in diabetic patients who are being considered for surgical sympathectomy.
