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Evaluation of diagnostic tests for Clostridium difficile infection.

Swindells, Jonathan; Brenwald, Nigel; Reading, Nathan; Oppenheim, Beryl.

J Clin Microbiol ; 48(2): 606-8, 2010 Feb.

Article in English | MEDLINE | ID: mdl-20032256

ABSTRACT

We evaluated toxigenic Clostridium difficile detection by a lateral flow assay for antigen and toxin, an enzyme immunoassay, and two commercial PCR methods. Compared to the cell cytotoxicity neutralization assay and toxigenic culture, both toxin detection methods lacked sensitivity. PCR following combined antigen and toxin detection provided the most useful diagnostic information.

Subject(s)

Clinical Laboratory Techniques/methods , Clostridioides difficile/isolation & purification , Diagnostic Tests, Routine/methods , Enterocolitis, Pseudomembranous/diagnosis , Immunoenzyme Techniques/methods , Polymerase Chain Reaction/methods , Aged , Aged, 80 and over , Antigens, Bacterial/analysis , Bacterial Toxins/analysis , Cell Culture Techniques/methods , Clostridioides difficile/chemistry , Clostridioides difficile/genetics , Humans , Neutralization Tests/methods

ABSTRACT

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