ABSTRACT
The benefits of dietary creatine supplementation on muscle performance are generally related to an increase in muscle phosphocreatine content. However, creatine supplementation may benefit endurance sports through increased glycogen re-synthesis following exercise. This study investigated the effect of creatine supplementation on muscle glycogen content, submaximal exercise fuel utilisation and endurance performance following 4 weeks of endurance training. Thirteen healthy, physically active, non-vegetarian subjects volunteered to take part and completed the study. Subjects were supplemented with either creatine monohydrate (CREAT, n = 7) or placebo-maltodextrin (CON, n = 6). Submaximal fuel utilisation and endurance performance were assessed before and after a 4 week endurance training program. Muscle biopsies were also collected before and following training for assessment of muscle creatine and glycogen content. Training increased quadriceps glycogen content to the same degree (approximately 20%) in both groups (P = 0.04). There was a significant training effect on submaximal fuel utilisation and improved endurance performance. However, there was no significant treatment effect of creatine supplementation. Creatine supplementation does not effect metabolic adaptations to endurance training.
Subject(s)
Adaptation, Physiological , Creatine/pharmacology , Dietary Supplements , Exercise/physiology , Physical Endurance/drug effects , Adolescent , Adult , Anthropometry , Carbohydrates/chemistry , Fats/metabolism , Female , Glycogen/analysis , Humans , Male , Muscle, Skeletal/drug effects , Muscle, Skeletal/metabolism , Oxidation-Reduction , Physical Endurance/physiologySubject(s)
Carpal Tunnel Syndrome/etiology , Leprosy, Tuberculoid/complications , Adult , Cambodia/ethnology , Carpal Tunnel Syndrome/ethnology , Carpal Tunnel Syndrome/pathology , Carpal Tunnel Syndrome/surgery , Female , Humans , Leprosy, Tuberculoid/ethnology , Leprosy, Tuberculoid/pathology , Leprosy, Tuberculoid/surgery , Median Nerve/pathology , Median Nerve/surgery , Recurrence , ReoperationABSTRACT
Data are presented on the effects of the use of pregnant mare serum gonadotrophin (PMS) and of increased liverweight on the number of lambs born, or in utero, in mature fine-woolled Merino ewes. The primary effect of increased bodyweight was to reduce the number of barren ewes whereas the main effect of PMS treatment was to increase the level of twinning among those ewes which conceived. The 2 effects appeared to be additive but it is pointed out that the survival rate of the lambs will be an important consideration in assessing the relative merits of the 2 treatments.
