ABSTRACT
PURPOSE: To investigate the effects of topical bimatoprost (0.3 mg/ml)/timolol maleate (5 mg/ ml) fixed combination on retrobulbar blood flow in patients with ocular hypertension (OHT). PATIENTS AND METHODS: Twenty consecutive patients with OHT were prospectively randomised to either bimatoprost/timolol or placebo during a 12 weeks double masked treatment trial. Examinations were performed at baseline and after 12 weeks of treatment. Visual acuity, intraocular pressure (IOP), slit-lamp examination, automated static perimetry, systemic blood pressure and heart rate were all recorded. Retrobulbar blood flow measurements of the ophthalmic artery (AO) and central retinal artery (CRA) were measured by colour Doppler imaging. RESULTS: IOP was significantly decreased by bimatoprost/timolol fixed combination (p < 0.0001). Bimatoprost/timolol fixed combination therapy resulted in a significant increase in end diastolic velocity (EDV) of the CRA (p = 0.03). In patients treated with bimatoprost/timolol a statistically significant correlation between IOP and EDV was observed after 12 weeks of treatment (r = -0.511, p = 0.045). The systolic (p = 0.54) and diastolic (p = 0.67) blood pressures and heart rate (p = 0.10) did not show statistically significant differences during the study period. CONCLUSIONS: Topical bimatoprost/timolol fixed combination significantly reduced IOP in patients with OHT. However, the only significant change observed in retrobulbar haemodynamics was an increase in EDV of the CRA, probably associated with a reduction in IOP.
Subject(s)
Amides/administration & dosage , Antihypertensive Agents/administration & dosage , Cloprostenol/analogs & derivatives , Eye/blood supply , Eye/diagnostic imaging , Ocular Hypertension/diagnostic imaging , Ocular Hypertension/physiopathology , Regional Blood Flow/drug effects , Timolol/administration & dosage , Ultrasonography, Doppler, Color , Amides/therapeutic use , Antihypertensive Agents/therapeutic use , Bimatoprost , Cloprostenol/administration & dosage , Cloprostenol/therapeutic use , Double-Blind Method , Drug Combinations , Female , Humans , Male , Middle Aged , Ocular Hypertension/drug therapy , Prospective Studies , Timolol/therapeutic useABSTRACT
Objetivo: Evaluar el efecto de la administración tópica de la combinación fija bimatoprost(0,3 mg/ml)/maleato de timolol (5 mg/ml) sobre el flujo sanguíneo retrobulbar en pacientescon hipertensión ocular (HTO).Pacientes y métodos: Veinte pacientes con HTO fueron incluidos en este estudio prospectivo,doble ciego y aleatorizados a recibir tratamiento con bimatoprost/timolol o placebo durante12 semanas. Las pruebas se llevaron a cabo en la primera visita y a las 12 semanas. Seregistraron la agudeza visual, presión intraocular (PIO), examen en lámpara de hendidura,perimetría estática automática, presión arterial sistémica y frecuencia cardíaca. Medianteecografía doppler color (EDC) se midieron los parámetros del flujo sanguíneo retrobulbarde la arteria oftálmica (AO) y arteria central de la retina (ACR).Resultados: La combinación fija bimatoprost/timolol redujo significativamente la PIO(p < 0,0001), además de conseguir un incremento significativo de la velocidad diastólicafinal (VDF) en la ACR (p = 0,03). En el grupo de pacientes tratados con bimatoprost/timololse observó una correlación estadísticamente significativa entre la PIO y la VDF a las 12semanas de tratamiento (r = 0,511, p = 0,045). No hubo cambios significativos en las presionesarteriales sistólica (p = 0,54) y diastólica (p = 0,67) ni en la frecuencia cardíaca(p = 0,10) durante el período de tratamiento.Conclusiones: La combinación fija bimatoprost/timolol redujo significativamente la PIO enpacientes con HTO. El único cambio observado en la hemodinámica retrobulbar fue unincremento de la VDF en la ACR, probablemente relacionado con la reducción de la PIO(AU)
Purpose: To investigate the effects of topical bimatoprost (0.3 mg/ml)/timolol maleate (5 mg/ml) fixed combination on retrobulbar blood flow in patients with ocular hypertension(OHT).Patients and methods: Twenty consecutive patients with OHT were prospectively randomisedto either bimatoprost/timolol or placebo during a 12 weeks double masked treatment trial.Examinations were performed at baseline and after 12 weeks of treatment. Visual acuity,intraocular pressure (IOP), slit-lamp examination, automated static perimetry, systemicblood pressure and heart rate were all recorded. Retrobulbar blood flow measurements ofthe ophthalmic artery (AO) and central retinal artery (CRA) were measured by colourDoppler imaging.Results: IOP was significantly decreased by bimatoprost/timolol fixed combination(p < 0.0001). Bimatoprost/timolol fixed combination therapy resulted in a significantincrease in end diastolic velocity (EDV) of the CRA (p = 0.03). In patients treated withbimatoprost/timolol a statistically significant correlation between IOP and EDV wasobserved after 12 weeks of treatment (r = 0.511, p = 0.045). The systolic (p = 0.54) anddiastolic (p = 0.67) blood pressures and heart rate (p = 0.10) did not show statisticallysignificant differences during the study period.Conclusions: Topical bimatoprost/timolol fixed combination significantly reduced IOP inpatients with OHT. However, the only significant change observed in retrobulbarhaemodynamics was an increase in EDV of the CRA, probably associated with a reductionin IOP(AU)
Subject(s)
Humans , Ocular Hypertension , Ultrasonography, Doppler, Color/methods , Eye/blood supply , Timolol/pharmacokinetics , Antihypertensive Agents/pharmacokinetics , Ophthalmic Artery , Retinal Artery , Visual Acuity , Drug CombinationsABSTRACT
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Subject(s)
Humans , Female , Adult , Horner Syndrome/diagnosis , Antidepressive Agents/pharmacokinetics , Anisocoria/diagnosis , Pupil Disorders/chemically inducedABSTRACT
We have performed this prospective study to address the question of whether there is an association between the outcome following cataract surgery and the distance from the patient's home to the place of surgery. Three hundred and forty consecutive out-patient extracapsular cataract extractions were evaluated. According to the distance, the cases were grouped into two categories, 183 cases in the nearest group (Group 1) and 157 cases in the farthest group (Group 2). A best corrected visual acuity of 0.5 or better was achieved in 90% of patients, 6 between the groups. No significant differences in rates for operative and postoperative complications were identified. This study does not show that the distance from the patient's home to the surgical site has had any adverse effect of surgical outcome or in rates of complications.
Subject(s)
Ambulatory Care Facilities , Ambulatory Care , Cataract Extraction , Transportation , Aged , Female , Humans , Male , Postoperative Complications , Postoperative Period , Prospective Studies , Treatment Outcome , Visual AcuityABSTRACT
We present a 12-year-old girl with Kenny-Caffey syndrome and bilateral optic atrophy. The results of testing in this patient and the ocular findings in the 25 previously reported cases with Kenny-Caffey syndrome are reviewed. This is the first case with such an association in the literature to date.
