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Eksp Klin Farmakol ; 73(10): 31-3, 2010 Oct.
Article in Russian | MEDLINE | ID: mdl-21254511

ABSTRACT

Toxicological experiments showed that the new benzimidazole derivative with hypoglycemic action--diabenol--influences the sexual activity and processes of female fertilization. The estrous cycle, sexual activity and quality of fertilization were activated at females upon the administration of diabenol in a therapeutic dose of 5 mg/kg. It is established that the drug administration in a toxic dose of 160 mg/kg suppresses the sexual activity and, at the same time, does not affect the estrous cycle and quality of fertilization in females.


Subject(s)
Benzimidazoles/adverse effects , Estrous Cycle/drug effects , Fertilization/drug effects , Hypoglycemic Agents/adverse effects , Sexual Behavior, Animal/drug effects , Animals , Benzimidazoles/pharmacology , Dose-Response Relationship, Drug , Female , Hypoglycemic Agents/pharmacology , Male , Rats
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