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Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells.
Hwang, HyunTae V; Tran, Darlene Thuy; Rebuffatti, Michelle Nicole; Li, Chin-Shang; Knowlton, Anne A.
PLoS One ; 13(1): e0190374, 2018.
Article in English | MEDLINE | ID: mdl-29315311

ABSTRACT

NEW AND NOTEWORTHY: Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.


Subject(s)
Cellular Senescence/drug effects , Endothelium, Vascular/drug effects , Quercetin/analogs & derivatives , Quercetin/pharmacology , Adult , Cell Proliferation/drug effects , Endothelium, Vascular/cytology , Female , Human Umbilical Vein Endothelial Cells , Humans
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