ABSTRACT
This retrospective study evaluates the results obtained in five Italian departments of traumatology in the treatment of peritrochanteric (pertrochanteric and subtrochanteric) fractures by the intramedullary hip screw (IMHS; Smith & Nephew Richards, Memphis, TN, USA) nail. One thousand two hundred and seventy-three patients were treated with the IMHS nail between March 1992 and February 2000. The results of these operations were evaluated clinically and radiological in 981 patients. The 90.3% of patients could walk unaided or with simple support. Because of the low complication rate requiring re-operation (postoperative shaft fractures, screw penetrated the acetabulum, cut out and non-union) (1.7%), we think that this device is an advance in the treatment of peritrochanteric fractures.
Subject(s)
Bone Screws , Hip Fractures/surgery , Adult , Aged , Aged, 80 and over , Female , Hip Fractures/diagnostic imaging , Hip Fractures/rehabilitation , Hip Joint/diagnostic imaging , Hip Joint/surgery , Humans , Intraoperative Complications/etiology , Italy , Male , Middle Aged , Postoperative Complications/etiology , Radiography , Retrospective Studies , WalkingABSTRACT
Isolated fractures of the capitate are uncommon. We report a rare case of isolated fracture of the capitate with dorsal dislocation of the proximal pole. After open reduction and K-wire fixation the fracture united, and a full range of wrist motion was achieved. No signs of avascular necrosis were observed after 3 years.
Subject(s)
Fracture Fixation/methods , Fractures, Closed/pathology , Joint Dislocations/pathology , Wrist Injuries/pathology , Adolescent , Bone Wires , Fractures, Closed/surgery , Humans , Joint Dislocations/surgery , Male , Range of Motion, Articular , Treatment Outcome , Wrist Injuries/surgeryABSTRACT
Inosiplex, a complex of inosine and 2-hydroxypropyldimethyl ammonium-4-(acetylamino)benzoate, 1:3 molar ratio, originally developed for antiviral use, is now under wider investigation because of its immunopotentiating properties. This compound can have some actions on T cells at various stages of differentiation, thus promoting an enhancement of their blastogenic responses to varied mitogenic agents (PHA, Con A, PWM, MLC, tetanus toxoid, and viral antigens). Our studies demonstrated that under the influence of inosiplex human peripheral blood T lymphocytes bearing Fc IgG receptors have an augmented receptor avidity for SRBC which result in an increased E active rosette formation, and that T cells preincubated with the drug at the appropriate concentrations express more Fc IgG receptors. Even though T gamma cells exert "in vitro" immunoregulatory properties, the increase in percentage of T gamma lymphocytes do not correlate with a potentiation of the Con A-induced suppressor activity of T cells. Moreover, the lymphocytes treated with the substance in the absence of Con A exert helper functions, increasing the mitogenic responses of the second culture PHA--treated lymphocytes. These data appear to suggest a pro-proliferative inosiplex-induced effect which could mask a concomitant suppressor cell induction.
Subject(s)
Inosine Pranobex/pharmacology , Inosine/analogs & derivatives , Receptors, Immunologic/metabolism , T-Lymphocytes/drug effects , Adjuvants, Immunologic , Adult , Cell Division/drug effects , Humans , In Vitro Techniques , Middle Aged , Receptors, IgG , Rosette Formation , T-Lymphocytes/metabolismABSTRACT
Circulating immune complexes were investigated by the E.A. and E.A.C. rosette inhibition test in sera samples from patients infested by Schistosoma haematobium. About 60% of the patients demonstrated significantly higher inhibition values than controls. The material inhibiting E.A.C. rosette formation was precipitated by 3.5% polyethilene glycol, thus excluding the role of C3 fragments and suggesting that inhibition was due to immune complexes.
