ABSTRACT
INTRODUCTION: Prostate cancer (CaP) is one of the most important causes of morbidity and mortality in the world. There is evidence that obesity and inadequate eating habits may promote CaP development. OBJECTIVE: To analyze and compare the body mass index (BMI) and the food intake, especially fats and antioxidants, among subjects with CaP and those free of disease as a control group. MATERIAL AND METHODS: A sample of 40 men between 50 and 80 years old were selected for the study: 20 with CaP and 20 healthy men as control group. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy, and a nutritional interview where a dietary history and different anthropometric measurements were made. Statistical analysis was performed using the Student T test for independent samples (p < 0.05). RESULTS: BMI in the subjects with CaP was higher than in controls (29.8 kg/m2 vs. 27.96 kg/m2, p = 0.13) but not statistically significant. However, there was a direct correlation between BMI and tumor aggressiveness (r = 0.79, P < 0.001). Total, saturated, monounsaturated and polyunsaturated fat intake was significantly higher in subjects with CaP; while omega3 fatty acids, vitamin C and lycopene intake was significantly lower than in controls (p < 0.05). CONCLUSIONS: A healthy weight and a diet low in total fat, saturated, monounsaturated and polyunsaturated fat and rich in n3 fatty acids, vitamin C and lycopene is associated with a lower risk of CaP.
Subject(s)
Body Mass Index , Diet , Prostatic Neoplasms/etiology , Aged , Aged, 80 and over , Antioxidants , Dietary Fats , Humans , Male , Middle Aged , Prostatic Neoplasms/epidemiologyABSTRACT
Introducción: El adenocarcinoma de próstata (CaP) es una de las causas más importantes de morbimortalidad en el mundo. La obesidad y los hábitos alimentarios inadecuados favorecerían el desarrollo del CaP. Objetivo: Analizar y comparar el índice de masa corporal (IMC) y la historia alimentaria, especialmente el consumo de grasas y antioxidantes, entre sujetos con CaP diagnosticado y sujetos libres de enfermedad. Material y Métodos: fueron seleccionados 40 hombres entre 50 y 80 años: 20 con cáncer de próstata diagnosticado y 20 libres de enfermedad como grupo control, a los cuales se les realizó tacto rectal, medición de antígeno prostático específico, ecografía transrectal y biopsia ecodirigida de próstata; y una entrevista nutricional que incluyó una historia dietética detallada y mediciones antropométricas. El análisis estadístico se realizó mediante Test de Student para muestras independientes (p<0,05).Resultados: El IMC en los sujetos con CaP fue superior que en los controles (29,8kg/m2 vs. 27,96kg/m2; p=0,13) aunque estadísticamente no significativo. Sin embargo, se observó una correlación directa entre el IMC y la agresividad del tumor (r=0,79; p<0.001). El consumo de grasas totales, saturadas, monoinsaturadas y poliinsaturadas fue significativamente mayor en los sujetos con CaP (p=0,001); mientras que la ingesta de ácidos grasos ω3, vitamina C y licopeno fue significativamente menor independientemente del Score de Gleason que presentasen (p<0,05).Conclusiones: Un peso saludable y una alimentación baja en grasas totales, saturadas, monoinsaturadas y poliinsaturadas y rica en ácidos grasos ω3, vitamina C y licopeno se asocia a un menor riesgo de CaP (AU)
Introduction: Prostate cancer (CaP) is one of the most important causes of morbidity and mortality in the world. There is evidence that obesity and inadequate eating habits may promote CaP development. Objective: To analyze and compare the body mass index (BMI) and the food intake, especially fats and antioxidants, among subjects with CaP and those free of disease as a control group. Material and Methods: A sample of 40 men between 50 and 80 years old were selected for the study: 20 with CaP and 20 healthy men as control group. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy, and a nutritional interview where a dietary history and different anthropometric measurements were made. Statistical analysis was performed using the Student T test for independent samples (p <0.05). Results: BMI in the subjects with CaP was higher than in controls (29.8 kg/m2 vs. 27.96 kg/m2, p = 0.13) but not statistically significant. However, there was a direct correlation between BMI and tumor aggressiveness (r = 0.79, P <0.001). Total, saturated, monounsaturated and polyunsaturated fat intake was significantly higher in subjects with CaP; while ω3 fatty acids, vitamin C and lycopene intake was significantly lower than in controls (p <0.05).Conclusions: A healthy weight and a diet low in total fat, saturated, monounsaturated and polyunsaturated fat and rich in ω3 fatty acids, vitamin C and lycopene is associated with a lower risk of CaP (AU)
Subject(s)
Middle Aged , Aged , Aged, 80 and over , Humans , Prostatic Neoplasms , Prostatic Neoplasms/epidemiology , Prostatic Neoplasms/etiology , Prostatic Neoplasms/mortality , Prostatic Neoplasms/diagnosis , Body Weight , Weight Gain , Dietary Fats , Antioxidants , Urologic Diseases , Urologic NeoplasmsABSTRACT
BACKGROUND: Many studies have investigated the association between obesity, adipose tissue-derived factors (leptin and adiponectin) and prostate cancer (CaP) but the results are still inconsistent. METHODS: The aim of this study was to carry out a comprehensive review of the existing evidence about the role of leptin and adiponectin in prostate carcinogenesis and to provide an overview of it. RESULTS: Recent evidence suggests that leptin may play a rol in prostate cancer progression, while adiponectin may act as an "antiprostatic cancer" adipokine. CONCLUSIONS: Obesity may promote the progression of established prostate cancer and and adipokines may provide a molecular mechanism whereby obesity exerts its effects on prostate tumour biology.
