Novel decorated aluminium(iii) phthalocyanine complex with the application of MWCNTs on electrodes: electrochemical non-enzymatic oxidation and reduction of glucose and hydrogen peroxide.

In this study, we performed the physicochemical and electrochemical characterization of a decorated macrocyclic aluminium(iii) phthalocyanine complex (AlTMQNCAPc). Subsequently, the AlTMQNCAPc@MWCNT/GC electrode was used for the electrochemical detection of glucose and hydrogen peroxide (H2O2) by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamperometry (CA). Moreover, the limit of detection, linear range, and sensitivity for glucose and H2O2 were investigated (CV: 2.5 nM L-1 and 25 nM L-1, 50-500 µM, 0.052 and 0.072 µA µmol cm-2; DPV: 3.1 nM L-1 and 18 nM L-1, 50-500 µM, 0.062 and 0.066 µA µmol cm-2 and CA: 10 nM L-1 and 20 nM L-1, 50-500 µM, 0.098 and 0.07 µA µmol cm-2, respectively). In addition, the AlTMQNCAPc@MWCNT/GC electrode showed good selectivity for the detection of glucose and H2O2 in the presence of common interfering substances, such as AA, DA, UA, glycine, l-cysteine, nitrite, Pb(ii), Cd(ii), Cu(ii), Co(ii), Hg(ii), Zn(ii), and glucose. For the detection of glucose and H2O2, the kinetic parameters, including the electron transfer coefficient and catalytic reaction rate constant, were also established. Finally, for usage in practical applications, the modified electrode was employed to achieve the quantitative detection of glucose and H2O2 in human urine and commercial samples of 3% H2O2, respectively.

Novel Schiff base cobalt(ii) phthalocyanine with appliance of MWCNTs on GCE: enhanced electrocatalytic activity behaviour of α-amino acids.

A novel tetra-4-{(E)-[(8-aminonaphthalen-1-yl)imino]methyl}-2-methoxyphenol Co(ii) phthalocyanine (CoTANImMMPPc) was synthesized using a precursor protocol and characterized via electroanalytical and spectroscopic techniques. The FT-IR spectra of the synthesized compounds showed significant peaks corresponding to the functional groups of the precursors and phthalocyanine (Pc) compound. The mass and NMR spectra confirmed the formation of the target precursor compounds. A film of CoTANImMMPPc was deposited on the surface of an electrode and applied for the detection and monitoring of l-alanine and l-arginine. The cyclic voltammetric studies of l-alanine and l-arginine using the (CoTANImMMPPc/MWCNTs/GC) electrode showed a linear response in the range of 50-500 nM and the limit of detection was found to be 1.5 and 1.2 nM, respectively. Differential pulse voltammetry and chronoamperometry showed that the catalytic response for l-alanine and l-arginine is in the range of 50-500 nM with an LoD of 1.8 and 2.3 nM, respectively. The oxidation-active CoTANImMMPPc film significantly enhanced the current response in the chronoamperometric method and displayed a selective and sensitive response towards l-alanine and l-arginine in the presence of various other bio-molecules. The developed electrode showed good working stability and was applied for the analysis of real samples, which yielded satisfactory results. Therefore, CoTANImMMPPc-MWCNTs/GCE shows good analytical performance, is economical and produced via a simple synthetic method and can be applied as a sensor for the detection of l-alanine and l-arginine.

Synthesis, antitumor, and DNA binding behavior of novel 4-(2-hydroxyquinolin-3-yl)-6-phenyl-5, 6 dihydropyrimidin derivatives in aqueous medium.

This article deals with the synthesis of 4-(2-hydroxyquinolin-3-yl)-6-phenyl-5,6-dihydropyrimidin derivatives (2a-f), on condensation with various aromatic aldehydes and ketones in aqueous ethanolic NaOH solution yielding the corresponding chalcones (3). These chalcones were further reacted with thiourea/urea in the presence of a base, which led to the formation of the titled derivatives (2a-f). The newly synthesized heterocyles were characterized by elemental analysis, FTIR, (1)HNMR, and electronic and mass spectral data. The compounds (2a and 2b) were evaluated for in vitro cyctotoxicity against human breast adenocarcinoma cell (MCF-7). In MTT cytotoxicity studies, both quinolinde derivatives were found most effective. The binding interaction behavior of the compound (2a) and (2d) with calf thymus-DNA (CT-DNA) was studied by electronic spectra, viscosity measurements, and thermal denaturation studies. On binding to CT-DNA, the absorption spectrum underwent bathochromic and hypochromic shifts. The binding constant (K(b)) observed 4.3 x 10(5) M(-1) for (2a), and 3.8 x 10(5) M(-1) for (2d) suggested that compound (2a) binds more strongly with base pairs than (2d).