ABSTRACT
Genes control approximately 60% to 75% of the variance of peak bone mass/density and a much smaller amount of variance in rate of loss. Bone mass increases during growth to a peak value and soon after begins to decline. Most of the genetic effect is exerted during growth and so influences peak bone mass; whether there is an additional genetic effect on the rate of bone loss is less clear. So, this article aims to place emphasis on various oral and systemic conditions that are manifested due to altered gene function. Genetic polymorphisms and mutations are simple, although the consequences of the mechanism are complex. The syndromic manifestation due to changes at genetic level will greatly affect the bone quality, which will ultimately affect any treatment prognosis. Hence, a better understanding of molecular mechanisms of bone remodeling helps to identify pathogenic causes of bone, skeletal diseases, and leads to the development of targeted therapies for these diseases. This review highlights notions on the connecting link between science and genetics as well as various oral scenarios where gene could bring about changes, resulting in deformities. There is an intense research awaited in the future which could intervene with the causes that bring about genetic modulations, so as to decrease the mortality rate of humans.
ABSTRACT
Facial defects resulting from neoplasm, congenital malformation, or trauma can be restored with facial prosthesis using different materials and retention methods to achieve the life-like appearance and facilitate function. A facial prosthesis can re-establish esthetic form and anatomic contours for midfacial defects, often more effectively than by surgical reconstruction. For successful results, a lot of factors such as harmony, texture, color matching, and blending of tissue interface with the prosthesis are important. This case report describes a novel approach to rehabilitate a patient who had underwent partial rhinectomy as a result of hemangiopericytoma of the nose. This article explains the construction of partial facial mask, which restored the defect involving the left lateral aspect of the nose, medial aspect of the left eye, and the part of the cheek.
ABSTRACT
BACKGROUND: Several methods, some physiological, some radiographical and some merely based on experience are taken upon by the practitioner to get him/her close to VDO in the edentulous patients. No single method can however claim to be the perfect answer. Lateral cephalograms have been a standard mode of determining the vertical dimensions in dentate and edentulous patients since the past. Due to unavoidable manual errors, there are chances of variations in the radiographic method too. Advancement in the digital technology has made recording jaw relations faster, simpler and more precise. AIM: This study compared the vertical dimension of occlusion in edentulous patients recorded by using three different physiological methods with the aid of digital cephalometric tracings using indigenously developed PRO-CEPH V3 software. MATERIALS AND METHODS: For the present study a total of 50 dentulous and 25 edentulous patients were selected through inclusion and exclusion criteria. A lateral cephalometric radiograph was taken for all the 50 dentulous subjects at Maximum Intercuspation (VDO) whereas three lateral cephalometric radiographs were obtained for all edentulous patients at the VDO following three different techniques- the Niswonger's method, Phonetics method and Swallowing threshold method. Cephalometric tracings were carried out using indigenously developed PRO-CEPH V3 software. Linear and angular measurement were made and analysed. CONCLUSION: The indigenously developed software PRO-CEPH V3 is capable of making both the linear and angular measurement and therefore provide with relative credibility information regarding the possible VDO in the edentulous patients through cephalometric radiography.
ABSTRACT
The most common site of fracture in a maxillary or a mandibular complete denture is along an anteroposterior line that coincides with the labial notch in in the denture which used to provide the frenum relief. Osseointegrated implants have been a boon to the patients who are completelly edentulous and are not satisfied with the conventional removable complete denture approach.Implant supported dentures have proven to provide superior retention and support for removable complete dentures. Nevertheless, fracture of the denture bases is a common complication of implant-supported mandibular overlay dentures,ecspecially when the artificial denture is opposing natural dentition. This article describes and illustrates a method of reinforcing implant-supported mandibular overdentures to overcome this problem.
