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Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles.
Padmavathi, V; Reddy, S Nagi; Reddy, G Dinneswara; Padmaja, A.
Eur J Med Chem ; 45(9): 4246-51, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20630628

ABSTRACT

A new class of oxadiazoles is prepared by treating aminosulfonylacetic acids with different carboxylic acid hydrazides. Interconversion of oxadiazoles to thiadiazoles is carried out with thiourea. The compounds are screened for antimicrobial and antioxidant activities.


Subject(s)
Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Antioxidants/chemistry , Antioxidants/pharmacology , Oxadiazoles/chemistry , Oxadiazoles/pharmacology , Thiadiazoles/chemistry , Anti-Infective Agents/chemical synthesis , Antioxidants/chemical synthesis , Bacteria/drug effects , Biphenyl Compounds/chemistry , Microbial Sensitivity Tests , Nitric Oxide/chemistry , Oxadiazoles/chemical synthesis , Picrates/chemistry
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