ABSTRACT
The results of intermittent normobaric hypoxytherapy in 42 patients with bronchial asthma (BA) and 14 patients with chronic obstructive bronchitis (COB) are analyzed. The positive effect is obtained in 76% of patients with BA and 92.8% of patients with COB. In the group of patients with BA the best effect was achieved for atopic form of BA--in 90% of patients, the effect was less pronounced for infection-allergic form--in 73.9% and for mixed form of BA--in 66.7%. In the process of treatment the attacks of asphyxia disappeared or became more occasional in 60.7% of patients; in 32.1% the attacks were more easily arrested or stopped independently; 33.8% of patients decreased doses of constantly taken drugs; in 33% cough ceased or decreased, sputum became to expectorate better; in 41% of patients dyspnea disappeared and considerably decreased. Improvement of the state in 54% of patients was retained for one year and more, in 29%--for 6 months, in 16.6%--for 3-4 months. The course of treatment consisted of 20-25 sessions. The patients breathed in hypoxic gas mixture containing 10% of oxygen (HGM-10) under intermittent conditions alternating with respiration of free air.
Subject(s)
Lung Diseases, Obstructive/therapy , Oxygen Inhalation Therapy , Adult , Asthma/diagnosis , Asthma/physiopathology , Asthma/therapy , Bronchitis/diagnosis , Bronchitis/physiopathology , Bronchitis/therapy , Female , Humans , Lung Diseases, Obstructive/diagnosis , Lung Diseases, Obstructive/physiopathology , Male , Middle Aged , Respiratory Function Tests , Time Factors , Treatment OutcomeABSTRACT
Evidences available in home and foreign literature concerning the effect of normobaric hypoxia, adaptation to mountain climate conditions and trainings in barochamber on cellular and humoral indices of immunity have been critically considered. The data on the influence of permanent residence under mountain conditions on the level of sickness rate of population, bioenergy indices, and activity of the opiate brain system have been studied as well. The analyzed data indicate that it is expedient to use normobaric hypoxia for effects on the state of immunic organism system.
Subject(s)
Altitude , Atmosphere Exposure Chambers , Climate , Hypoxia/immunology , Acute Disease , Adaptation, Physiological , Animals , Antibody Formation , Chronic Disease , Humans , Hypoxia/metabolism , Immunity, Cellular , Lipid Peroxidation , Mice , Narcotics/metabolism , PhagocytosisABSTRACT
IgE- and IgG-reagins were investigated in the sera of 120 patients with atopic bronchial asthma. Two clinicopathogenetic variants of disease were defined with relation to the genetic variants of disease were defined with relation to the main immunological mechanism: IgE-dependent (in 78 patients) and IgE-IgG-dependent (in 42 patients). Variations in a clinical picture, the results of specific allergological examination, the level of total serum IgE in different variants of the atopic form of bronchial asthma were established. Specific immunotherapy produced a good effect in the IgE-dependent variant. In the patients with the IgE-IgG-dependent variant specific immunotherapy with a house dust allergen proved to be ineffective in most cases.
