Subject(s)
Bacteroides Infections/etiology , Bacteroides/pathogenicity , Peritonitis/etiology , Adult , Ascitic Fluid/microbiology , Bacteroides/isolation & purification , Bacteroides Infections/diagnosis , Bacteroides Infections/microbiology , Female , Humans , Peritonitis/diagnosis , Peritonitis/microbiologyABSTRACT
In two separate research centres the ability of RO 15-4513 to protect rats against the lethal effects of ethanol (7.5 and 15 g/kg) was investigated. In neither study did RO 15-4513 offer protection against ethanol-induced lethality or the loss of righting reflex caused by these doses of ethanol. These data fail to replicate the results of an earlier report and suggest that RO 15-4513 is unlikely to be clinically useful treating acute severe ethanol toxicity.
Subject(s)
Azides/pharmacology , Benzodiazepines/pharmacology , Ethanol/antagonists & inhibitors , Animals , Ethanol/toxicity , Male , Postural Balance/drug effects , Rats , Rats, Inbred Strains , Reflex/drug effects , Time FactorsABSTRACT
Trimethoprim-sulfamethoxazole continues to be a useful antibiotic for common outpatient problems such as urinary tract infections, prostatitis, acute exacerbations of chronic bronchitis, and acute otitis media as well as for serious infections of the hospitalized patient including Pneumocystis carinii pneumonia, acute pyelonephritis, and some forms of gram negative meningitis. The other sulfonamides have a limited role.
Subject(s)
Anti-Infective Agents/therapeutic use , Bacterial Infections/drug therapy , Sulfamethoxazole/therapeutic use , Sulfonamides/therapeutic use , Trimethoprim/therapeutic use , Anti-Infective Agents/adverse effects , Anti-Infective Agents/pharmacokinetics , Drug Combinations/adverse effects , Drug Combinations/pharmacokinetics , Drug Combinations/therapeutic use , Humans , Sulfamethoxazole/adverse effects , Sulfamethoxazole/pharmacokinetics , Sulfonamides/adverse effects , Sulfonamides/pharmacokinetics , Trimethoprim/adverse effects , Trimethoprim/pharmacokinetics , Trimethoprim, Sulfamethoxazole Drug CombinationABSTRACT
The incidence of hypoprothrombinemia (prothrombin time greater than or equal to 2 s above the highest control) associated with concurrent cefamandole nafate usage in our institution was determined. Of 77 patients receiving cefamandole for no less than 48 hours, serial prothrombin time was monitored in 31 (40.2%). Four (12.9%) of 31 in whom a baseline normal prothrombin time was obtained developed hypoprothrombinemia during cefamandole therapy. An additional three patients for whom baseline prothrombin time was not determined were noted to have hypoprothrombinemia during therapy with cefamandole. Two patients had clinically significant bleeding episodes. The prothrombin time normalized in six of seven patients following administration of fresh frozen plasma, phytonadione therapy, discontinuation of cefamandole, or a combination of the three. This study illustrated that the incidence of hypoprothrombinemia associated with concurrent cefamandole use is relatively high. Serial prothrombin time monitoring is indicated when patients receive cefamandole.
Subject(s)
Cefamandole/adverse effects , Hospitals, Rural , Hospitals, Teaching , Hospitals , Hypoprothrombinemias/chemically induced , Adult , Aged , Female , Humans , Hypoprothrombinemias/epidemiology , Male , Middle Aged , Nafcillin/adverse effects , New York , Oxacillin/adverse effects , Prothrombin Time , Retrospective Studies , Time FactorsABSTRACT
Mild diarrhea of poorly documented volume is common early in the course of Legionella infection. We report massive diarrhea of 1.8 to 3 liters per day in a patient with pneumonia in whom Legionella micdadei was isolated from pleural fluid and infection was confirmed serologically. The large volume of diarrhea, not previously associated with Legionella infection, remained unexplained despite clinical evaluation and postmortem study of the gastrointestinal tract. This case expands the clinical spectrum of Legionnaires' disease to include massive diarrhea, which in our patient constituted the chief complaint.
Subject(s)
Diarrhea/etiology , Legionnaires' Disease/complications , Humans , Legionnaires' Disease/diagnosis , Male , Middle AgedSubject(s)
Chickens/metabolism , Resorcinols/metabolism , Zearalenone/metabolism , Animals , Eggs/analysis , Female , Ovulation , Tissue DistributionABSTRACT
The in vitro susceptibility of 145 anaerobic clinical isolates and 96 gram-positive aerobic clinical isolates to josamycin, a new macrolide antibiotic, was studied using the agar dilution technique. Ninety-five of the aerobes were susceptible to 1.56 mug or less of josamycin per ml. The median minimal inhibitory concentration of these organisms was
