ABSTRACT
The efficacy of the atypical antipsychotic risperidone was evaluated in the treatment of aberrant behavior (e.g., aggression, self-injury) in 20 individuals with developmental disabilities. A double-blind, crossover design was used to compare risperidone with placebo in a 22-week trial with a 6-month follow-up phase. Based on a 50% reduction in mean Aberrant Behavior Checklist--Community total scores, 50% of the participants were identified as responders. Naturalistic observations of a subset of five individuals showed that for 4 out of 5 participants, risperidone was effective in reducing aberrant behavior. Side effects included weight gain (84% of participants) and sedation (40% of participants). The advantages of conducting a comprehensive analysis of the effects of medication on aberrant behavior are discussed.
Subject(s)
Aggression/drug effects , Intellectual Disability/drug therapy , Risperidone/therapeutic use , Self-Injurious Behavior/drug therapy , Adolescent , Adult , Aged , Child , Cross-Over Studies , Dose-Response Relationship, Drug , Double-Blind Method , Female , Follow-Up Studies , Humans , Intellectual Disability/diagnosis , Intellectual Disability/psychology , Male , Middle Aged , Risperidone/adverse effects , Self-Injurious Behavior/diagnosis , Self-Injurious Behavior/psychology , Treatment OutcomeABSTRACT
A treatment package consisting of a DRO procedure, token fines, and prompted relaxation was used to reduce the agitated-disruptive behavior of a person with autism and mental retardation living in a community group home. The agitated-disruptive behaviors (cursing, hitting, kicking, throwing objects, and verbal threats) were measured during three different activities in a group home. The baseline rates of the agitated-disruptive behavior during one of these activities was relatively low, during another was moderate, and during the third was high. DRO procedures were partially implemented by a peer with Down syndrome and mental retardation during a portion of the study. Effects of the DRO procedures were as follows: During each activity an initial reduction of agitated-disruptive behavior was dependent on choosing an appropriate DRO interval, with shorter DRO intervals required during activities in which the baseline rates of the agitated-disruptive behavior were higher. Once shorter DRO intervals had been used to reduce agitated-disruptive behavior, longer DRO intervals were effective in maintaining those reductions. Reductions were maintained for up to 6 months.
