Synthesis of N,N'-bis(1,5-dimethyl-2-phenyl-1,2-dihydro-3-oxopyrazol-4-yl) sebacamide that ameliorate osteoarthritis symptoms and improve bone marrow matrix structure and cartilage alterations induced by monoiodoacetate in the rat model: "Suggested potent anti-inflammatory agent against COVID-19".

To assess the chondroprotective effect and influence of N,N'-bis(1,5-dimethyl-2-phenyl-1,2-dihydro-3-oxopyrazol-4-yl) sebacamide (dpdo) that was synthesized through the reaction of phenazone with sebacoyl chloride and screened for its biological activity especially as anti-arthritic and anti-inflammatory agent in a monoiodoacetate (MA)-induced experimental osteoarthritis (OA) model. Thirty male albino rats weighing "190-200 g" were divided randomly into three groups (10 each): control, MA-induced OA, and MA-induced OA + dpdo. In MA-induced OA rat, the tumor necrosis factor alpha, interleukin 6, C-reactive protein, rheumatoid factors, reactive oxygen species, as well as all the mitochondrial markers such as mitochondria membrane potential, swelling mitochondria, cytochrome c oxidase (complex IV), and serum oxidative/antioxidant status (malondialdehyde level and activities of myeloperoxidase and xanthine oxidase) are elevated. Also, the activity of succinate dehydrogenase (complex II), levels of ATP, the level of glutathione (GSH), and thiol were markedly diminished in the MA-induced OA group compared to the normal control rats. These findings showed that mitochondrial function is associated with OA pathophysiological alterations and high gene expressions of (IL-6, TNF-a, and IL-1b) and suggests a promising use of dpdo as potential ameliorative agents in the animal model of OA and could act as anti-inflammatory agent in case of severe infection with COVID-19. It is clearly appeared in improving the bone cortex and bone marrow in the treated group with the novel compound in histological and transmission electron microscopic sections which is a very important issue today in fighting severe infections that have significant effects on the blood indices and declining of blood corpuscles like COVID-19, in addition to declining the genotoxicity and inflammation induced by MA in male rats. The novel synthesized compound was highly effective in improving all the above mentioned parameters.

EFFECT OF INDOMETHACIN AND ITS COMPLEXES ON REPRODUCTIVE PERFORMANCE AND OXIDATIVE STRESS IN TESTIS AND STOMACH OF MALE ALBINO RATS WITH REFERENCE TO THEIR CHEMICAL CHARACTERIZATIONS.

Four new complexes of Hg (II), Pb (II), Sn (II) and Bi (III) with indomethacin drug ligand (IMC) were synthesized and characterized by using infrared, electronic, 1H-NMR spectral, thermogravimetric and conductivity measurements. The IMC was found to act as bidentate chelating agent. IMC complexes coordinate through the oxygen of the carboxyl group. The molar ratio chelation is 1:2 (M2+:IMC) with general formula [M (IMC) 2], nH2O for Hg (II), Pb(II) and Sn(II), but 1:3 for Bi(III) ions. Antibacterial screening of these heavy metal complexes against Escherichia coli (Gram-ve), Bacillus subtilis (Gram +ve) and anti-fungi (Asperagillus oryzae, Asperagillus niger, Asperagillus Flavus) were investigated. In the present study, we found evidence suggesting that Bi+3/IMC possesses the capacity to protect the stomach, sperm, testes, cellular ATP, cellular NAD, INSL3, PGD2, PGE2 and antioxidant enzymes from deleterious actions of IMC.

Synthesis, spectroscopic and thermal characterization of some transition metal complexes of folic acid.

Compounds having general formula: [M(FO)(Cl)x(H2O)y]x zH2O, where (M=Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II), FO=folate anion, x=2 or 4, y=2 or 4 and z=0, 1, 2, 3, 5 or 15) were prepared. The obtained compounds were characterized by elemental analysis, infrared as well as electronic spectra, thermogravimetric analysis and the conductivity measurements. The results suggested that all folate complexes were formed by 2:1 molar ratio (metal:folic acid) as a bidentate through both of the two carboxylic groups. The molar conductance measurements proved that the folate complexes are electrolytes. The kinetic thermodynamic parameters such as: E*, DeltaH*, DeltaS* and DeltaG* were estimated from the DTG curves. The antibacterial evaluation of the folic acid and their complexes was also done against some Gram positive/negative bacteria as well as fungi.

Spectral properties of new N,N'-bis-alkyl-1,4,6,8-naphthalenediimide complexes.

The photophysical properties of two N,N'-bis-alkyl-1,4,6,8-naphthalenediimide (DCN1 and DCN2) have been studied in chloroform and N,N-dimethylformamide solvents. The ability of DCN2 in N,N-dimethylformamide to detect metal cations have been monitored by the fluorescence emission spectroscopy. It has been shown that the fluorescent intensity is very sensitive to the concentration of Fe3+ cations. The reaction of iodine with N,N'-bis-alkyl-1,4,6,8-naphthalenediimide in chloroform solution have been investigated by spectrophotometric method. The results indicate the formation of two CT-complexes [(DCN1)I]+.I3- and [(DCN2)I]+.I3- at donor:acceptor molar ratio of 1:2. The [(DCN1)I]+.I3- shows the characteristic absorptions of I3- ion at 290 and 360 nm while the charge-transfer transition of [(DCN2)I]+.I3- occurs at 310 nm. Three characteristic bands at the far infrared region in each iodine complex are observed around 135, 105 and 85 cm-1 due to nuas (I-I), nus (I-I) and delta (I3-), respectively with C2v symmetry. The values of the complex formation constant, K, and the absorptivity, epsilon have been calculated.

Charge-transfer interaction of iodine with some polyamidoamines.

The interaction of iodine as a sigma-acceptor with two derivatives of polyamidoamine dendrimers (donor), 1,8-naphthalimide polyamidoamine (PAM1) and 4-piperidino-1,8-naphthalimide polyamidoamine (PAM2) have been investigated spectrophotometrically at room temperature in chloroform. The results indicate the formation of two CT-complexes [(PAM1)I](+)I(3)(-) and [(PAM2)(2)I](+)I(3)(-) with molar ratios of 1:2 and 1:1, respectively. The formation of these two complexes are in good agreement with their elemental analysis, infrared measurements and photometric titration plots based on the characteristic absorption bands of I(3)(-) ion around 280 and 360 nm. Moreover the formation of triiodide ion, I(3)(-), in both of the two complexes was supported by measuring their spectra in the far-infrared region. Three characteristic bands are observed at 125, 110 and 75 cm(-1) due to nu(as)(I-I), nu(s)(I-I) and delta(I(3)(-)), respectively, with C(2v) symmetry.

A novel method for preparation of cobalt(II) and lead(II) carbonates.

Cobalt(II) carbonate, CoCO3.4H2O and lead(II) carbonate, PbCO3.2H2O were synthesis by a new simple method during the reaction of aqueous solutions of CoX2 (X=Cl-, NO3- and CH3COO-) and PbX2 (X=NO3- or CH3COO-), respectively, with urea at approximately 85 degrees C for 2 h. The infrared spectra of the reaction products clearly indicates the absence of the bands due to coordinated urea, but show the characteristic bands of ionic carbonate. A general mechanisms describing the formation of cobalt and lead carbonates are suggested.

Spectroscopic studies on charge-transfer complexes formed in the reaction of ferric(III) acetylacetonate with sigma- and pi-acceptors.

The reaction of ferric(III) acetylacetonate (donor), Fe(acac)3, with iodine as a sigma-acceptor and with other different pi-acceptors have been studied spectrophotometrically at room temperature in chloroform. The pi-acceptors used in this investigation are 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), p-chloranil and 7,7',8,8'-tetracyanoquinodimethane (TCNQ). The results indicate the formation of 1:1 charge-transfer complexes with a general formula, [Fe(acac)3 (acceptors)]. The iodine complex was shown to contain the triiodide species, [Fe(acac)3]2I(+)I3-, based on the electronic absorptions as well as on the Far-infrared absorption bands characteristic for the non-linear triiodide species, I3-, with C2v symmetry. The proposed structure of this complex is further supported by thermal and middle infrared measurements.