Subject(s)
Biopsy, Large-Core Needle/adverse effects , Gastrointestinal Hemorrhage/etiology , Postoperative Hemorrhage/etiology , Prostate/pathology , Prostatic Neoplasms/pathology , Rectal Diseases/etiology , Aged , Erythrocyte Transfusion , Gastrointestinal Hemorrhage/therapy , Humans , Male , Platelet Transfusion , Postoperative Hemorrhage/therapy , Prostatic Neoplasms/diagnosis , Rectal Diseases/therapyABSTRACT
BACKGROUND: Many approaches have been considered to reduce heart failure (HF) readmissions. The Joint Commission on Accreditation of Health Care Organizations (JC) requires hospitals to provide patients admitted for HF with discharge instructions that address 6 topics related to HF management: diet, exercise, weight monitoring, worsening symptoms, medications, and follow-up appointments. These guidelines were developed based on expert opinion, but no one has tested whether patients' understanding of these instructions affects 30-day readmission rates. METHODS AND RESULTS: We conducted a prospective cohort study of patients admitted for decompensated HF. Patients completed an understanding survey immediately after their nurse read their discharge papers. The survey contained 1 question for each of the 6 JC topics. Of the 145 patients in the study, only 14 (10%) understood all 6 discharge instructions. Patients with complete comprehension of their discharge instructions were significantly less likely to be readmitted within 30 days than those with nonperfect understanding (P = .044), but this association was no longer significant after controlling for level of education and use of English as a primary language. CONCLUSIONS: HF patients' comprehension of discharge instructions is inadequate. Patients with limited education and those that do not speak English as a primary language are more likely to have poorer discharge understanding and higher rates of 30-day readmissions.
Subject(s)
Comprehension , Heart Failure/epidemiology , Patient Discharge Summaries/standards , Patient Education as Topic/standards , Patient Readmission/statistics & numerical data , Communication Barriers , Educational Status , Female , Health Literacy , Humans , Joint Commission on Accreditation of Healthcare Organizations , Male , Middle Aged , Prospective Studies , Surveys and Questionnaires , United States/epidemiologyABSTRACT
PURPOSE: Acellular nerve allograft is a new option for bridging nerve defects that allows appropriate diameter matching. The aim of the study was to compare the histologic and functional recovery of nerve defects treated with acellular nerve allograft versus cabled sural nerve autograft. METHOD: Fifty-four Sprague-Dawley rats were divided into one of three experimental groups. A unilateral 10 mm sciatic nerve defect was created and repaired with an acellular nerve allograft (Group A), three cabled sural nerve autografts in antidromic orientation (Group B), and the newly created segmental defect in antidromic orientation (reversed autograft) (Group C). Two rats in each group we evaluated histologically at 6 weeks while the rest of the groups were tested histologically and functionally at 12 weeks. RESULTS: There were no differences in histomorphometry between the groups at 6 weeks, but at 12 weeks at mid-graft there were differences. Group C had the highest fiber count which was statistically greater when compared to Group A (P = 0.023) and when compared to Group B (P = 0.001). The average normalized maximum isometric tetanic force (ITF) was 52 ± 2.9% for Group A, 34.1 ± 4.2% for Group B, and 51.3 ± 3.3% for Group C at 12 weeks. There was no statistical difference between Groups A and C, but Group A was statistically greater when compared to B, and when Group C was compared to B. CONCLUSION: In conclusion, acellular nerve allograft demonstrated equal functional recovery when compared to reversed autograft (control), and superior recovery compared to the cabled nerve autograft.
Subject(s)
Nerve Transfer/methods , Peripheral Nerve Injuries/surgery , Action Potentials , Allografts , Animals , Autografts , Disease Models, Animal , Muscle, Skeletal/physiopathology , Peripheral Nerve Injuries/physiopathology , Rats , Rats, Sprague-Dawley , Rats, Wistar , Recovery of Function , Sciatic Nerve/injuries , Sciatic Nerve/pathology , Sciatic Nerve/surgery , Sural Nerve/pathology , Sural Nerve/transplantationABSTRACT
The 10 mm rat sciatic nerve defect model is commonly used to investigate new strategies to improve functional recovery with segmental nerve defects. However, a lack of standardization makes comparisons between studies difficult. The present study aims to evaluate a standardized experimental model that can minimize the number of animals required for obtaining valid results and simulates a current treatment for human peripheral nerve injury defects. Eighteen cadaveric Sprague-Dawley rats were utilized in the anatomic arm of the study and 18 living Sprague-Dawley rats were used in the experimental arm. The results from the cadaveric study allowed us to create an ipsilateral, three-cable autologous sural nerve graft technique in the rat. This repair construct was evaluated with functional and histomorphometric analysis of nerve regeneration. The results support functional recovery of the sciatic nerve in all grafted animals. The use of an ipsilateral cabled sural nerve graft technique in the rat sciatic nerve defect model is a viable control group that utilizes a single incision, incurs minimal morbidity, and maintains muscle attachments. We conclude that this rat model can be used in various experimental trials in the field of peripheral nerve regeneration.