ABSTRACT
Carcinoma of the vulva has commonly been recognized as a disease of postmenopausal women, although some series have noted up to 15% of cases occur in women under the age of 40 years. The following is a report of a case of invasive vulvar carcinoma diagnosed and treated with radical surgery during pregnancy. Recommendations for treatment of this disease during pregnancy are presented and guidelines for subsequent route of delivery are proposed. A review of previously reported cases is also presented.
Subject(s)
Carcinoma, Squamous Cell/epidemiology , Pregnancy Complications, Neoplastic/epidemiology , Vulvar Neoplasms/epidemiology , Adult , Carcinoma, Squamous Cell/surgery , Female , Humans , Infant, Newborn , Pregnancy , Pregnancy Complications, Neoplastic/surgery , Vulva/surgery , Vulvar Neoplasms/surgeryABSTRACT
An improved assay for the simultaneous assessment of phagocytic uptake (via immunobeads) and metabolic integrity (via NBT dye reduction) in neutrophils is described. Normal human neutrophils exhibited ingestion and dye reduction, whereas neutrophils from newborn cord blood showed ingestion with slight reduction and neutrophils from patients with chronic granulomatous disease displayed hyper-ingestion and no subsequent dye reduction.
