ABSTRACT
To study the relationship between the level of exposure to manganese and nickel and prolactin levels in the serum in women with Ñolycystic ovary syndrome (PCOS). 35 women with PCOS and 38 healthy women of reproductive age were examined. All women lived in Kiev. Manganese and nickel indices were determined in serum by the method of an Ñnductively coupled plasma mass spectrometry. The study of the ecological situation was carried out by analyzing open sources of information. Our study has shown that women with PCOS show an increase in manganese and nickel serum levels. Also significantly higher levels of prolactin was found. In the group of women with PCOS, elevated serum manganese concentrations correlated with an increase in prolactin levels (P=0.0134). There was no correlation between the levels of prolactin and the concentration of nickel in the serum of patients with PCOS. In healthy women, no correlation of prolactin and manganese or nickel levels was found. These results confirm the existing view that exposure to manganese may be the cause of increased levels of prolactin. Nickel exposure does not affect prolactin levels. Women with PCOS show an increase in prolactin levels, that depends on the level of exposure to manganese. This data suggest that an increased level of exposure with manganese can be attributed to factors or co-factors for the occurrence of PCOS. Nickel exposure does not affect prolactin levels.
