One year of surgical mask testing at the University of Bologna labs: Lessons learned from data analysis.

The outbreak of SARS-CoV-2 pandemic highlighted the worldwide lack of surgical masks and personal protective equipment, which represent the main defense available against respiratory diseases as COVID-19. At the time, masks shortage was dramatic in Italy, the first European country seriously hit by the pandemic: aiming to address the emergency and to support the Italian industrial reconversion to the production of surgical masks, a multidisciplinary team of the University of Bologna organized a laboratory to test surgical masks according to European regulations. The group, driven by the expertise of chemical engineers, microbiologists, and occupational physicians, set-up the test lines to perform all the functional tests required. The laboratory started its activity on late March 2020, and as of the end of December of the same year 435 surgical mask prototypes were tested, with only 42 masks compliant to the European standard. From the analysis of the materials used, as well as of the production methods, it was found that a compliant surgical mask is most likely composed of three layers, a central meltblown filtration layer and two external spunbond comfort layers. An increase in the material thickness (grammage), or in the number of layers, does not improve the filtration efficiency, but leads to poor breathability, indicating that filtration depends not only on pure size exclusion, but other mechanisms are taking place (driven by electrostatic charge). The study critically reviewed the European standard procedures, identifying the weak aspects; among the others, the control of aerosol droplet size during the bacterial filtration test results to be crucial, since it can change the classification of a mask when its performance lies near to the limiting values of 95 or 98%.

The impact of COVID-19 and the economic crisis on Lebanese public health: Food insecurity and healthcare disintegration.

Background: The economic crisis in Lebanon, a middle-income eastern Mediterranean country, has been threatening the health of the local population. This review will look at the impact of the economic crisis and COVID-19 on health and healthcare in the country, discussing food insecurity and water shortages, and the hospital crisis for what concerns medications, electricity shortages and workforce issues. Methodology: Peer Reviewed Literature produced between 2015 and 2021, indexed in Pubmed, Scopus and Google Scholar was used to compile this short report. News and governmental reports, alongside reports of NGOs like Médicins sans frontières were also collected; these were analysed for the production of this short report. Results: The challenges and public health consequences caused by the economic crisis and the COVID-19 pandemic in Lebanon were identified and commented upon. From food insecurity and water shortages, to the Beirut port explosion and the 2021 lack of fuel and electricity, it was found that the health and well-being of the Lebanese population is currently being threatened from many points of view. With food inflation rates rapidly escalating in 2020 and peaking at 441% in October, new-born and infant milk being non-existent and 20 hour power cuts daily, the situation in Lebanon does not seem to be improving. The country needs to receive international help to relief the population from these synergetic crises. Conclusion: Long-term economic reforms with an emphasis on employment should be at the forefront of the government's priority list. International help should also be provided to prevent disasters like food insecurity and electricity shortages from posing threats to the lives and the wellbeing of the people in Lebanon again.

Modeling ventilation time in forage tower silos.

The fermentation process in forage tower silos produces a significant amount of gases, which can easily reach dangerous concentrations and constitute a hazard for silo operators. To maintain a non-toxic environment, silo ventilation is applied. Literature reviews show that the fermentation gases reach high concentrations in the headspace of a silo and flow down the silo from the chute door to the feed room. In this article, a detailed parametric analysis of forced ventilation scenarios built via numerical simulation was performed. The methodology is based on the solution of the Navier-Stokes equations, coupled with transport equations for the gas concentrations. Validation was achieved by comparing the numerical results with experimental data obtained from a scale model silo using the tracer gas testing method for O2 and CO2 concentrations. Good agreement was found between the experimental and numerical results. The set of numerical simulations made it possible to establish a simple analytical model to predict the minimum time required to ventilate a silo to make it safe to enter. This ventilation time takes into account the headspace above the forage, the airflow rate, and the initial concentrations of O2 and CO2. The final analytical model was validated with available results from the literature.

Effect of hypoxia/reoxygenation on the contractility of the isolated bovine digital vein.

The bovine digital vasculature contractility has been implicated in the development of laminitis. To investigate the effect of hypoxia/reoxygenation on the contractility of isolated peripheral bovine digital veins (BDVs), vessel rings were studied under isometric conditions and submitted to 30 min of hypoxia (95%N(2)-5%CO(2)) and reoxygenation (95%O(2)-5%CO(2)) conditions, respectively. The BDVs contracted with a high K(+) depolarizing solution, developed hypoxia-induced relaxation, followed by an increase in tension upon reoxygenation. In contrast, phenylephrine-contracted BDVs displayed a rapid, sustained and reversible hypoxia-induced contraction. Reoxygenation caused a rapid relaxation in phenylephrine-contracted BDVs. The presence of the endothelium did not modify the hypoxia/reoxygenation effects and hypoxia-induced contraction was still observed in a nominal Ca(2+)-free Krebs, however, the last effect was not maintained over time. The hypoxia-induced contraction in an isolated peripheral vein may contribute to the understanding of the physiology and pathophysiology of superficial venous smooth muscle contractility, particularly in the alteration of bovine digital haemodynamics under hypoxia/reoxygenation conditions.

[Primary hyperoxaluria and pregnancy]. / L'iperossaluria primaria e gravidanza.

A rare case of pregnancy in a patient with primary hyperoxaluria type 1 is reported offering a clinical contribution for the prognostic study of a natural event such as the pregnancy on these patients. It is underlined how epicriticity of the hepatorenal system is remarkably altered during the last weeks of pregnancy with a great increase of calciuria and proteinuria with a risk of life for the patient and the newborn. In fact, during the 36rd week a caesarean section was performed due to gestosis. Moreover, the deterioration of kidney functionality doesn't decrease during post partum. Therefore, it would be advisable inform these patients about the risk of pregnancy.

Arteritis de Takayasu. Diagnóstico por resonancia magnética nuclear / Takayasu arteritis. Diagnoses by nuclear magnetic resonance

La arteritis de Takayasu es una vasculitis de etiología desconocida que afecta grandes vasos.El diagnóstico se realiza por medio de los criterios propuestos por el American College of Rheumatology,uno de los cuales es la angiografía.Presentamos un paciente que reunía criterios para arteritis de Takayasu en quien se realizó resonancia magnética nuclear en reemplazo de la angiografía.

Arteritis de Takayasu. Diagnóstico por resonancia magnética nuclear / Takayasu arteritis. Diagnoses by nuclear magnetic resonance

La arteritis de Takayasu es una vasculitis de etiología desconocida que afecta grandes vasos.El diagnóstico se realiza por medio de los criterios propuestos por el American College of Rheumatology,uno de los cuales es la angiografía.Presentamos un paciente que reunía criterios para arteritis de Takayasu en quien se realizó resonancia magnética nuclear en reemplazo de la angiografía.

Postoperative irradiation of brain ependymomas. Analysis of 33 cases.

Treatment and final outcome of 33 patients with brain ependymoma were reviewed. All patients had been operated, but the surgical removal was incomplete in the great majority of cases. Radiation therapy was subsequently performed using one of the following techniques; a) partial brain irradiation against the primary involved areas in 17 cases, b) whole brain irradiation plus boost against primary involved sites in 6 cases and c) total craniospinal irradiation in 7 cases. Three patients were not eligible for the present study because of underdosage. Five- and 10-year survival rates were 48 and 38% respectively. A short survey of recent literature is presented. The possible causes of failure and the methods for postoperative irradiation are discussed against the background of literature and our own cases.

Accuracy of computed tomography in the screening of obstructive jaundice.

Percutaneous transhepatic cholangiography (PTC) has come back into greater use thanks to Chiba's needle. PTC, however, is useful only in obstructive jaundice (OJ). Since in OJ the dilatation of the intrahepatic biliary tract (IHBTD) is constant, the authors discussed CTs reliability in evaluating IHBTD in a series of 33 patients with OJ studied with PTC. The threshold of CT diagnosis of IHBTD was found to be equal to a doubled caliber of the normal biliary tract. This value is reached by 85% of the patients 2 weeks after the onset of OJ and in 98% between 2 and 3 weeks. CT is therefore usable as a screening method of PTC, as long as it is not performed before 2 weeks after the onset of OJ. After 2 weeks, if CT does not reveal IHBTD, it is possible to exclude OJ.

[Surgery in radioactive patients (author's transl)]. / Interventi chirurgici su pazienti portatori di radioattività.

The authors discuss some legal aspects and protection problems relative to surgical procedures involving radioactive patients, also in the light of recent European guidelines. They analyse in particular the radiation risk associated with the more common cases concerning radioactive substances that are administered for diagnostic purposes. This study affords a preliminary evaluation of the risk inherent in such surgery, in the light of experimental measurements.