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J Basic Clin Physiol Pharmacol ; 32(4): 783-787, 2021 Jun 25.
Article in English | MEDLINE | ID: mdl-34214373

ABSTRACT

OBJECTIVES: This study was conducted to assess adverse drug reactions and their management in MDR-TB patients. Indonesia is the fifth highest country with multidrug-resistant tuberculosis (MDR-TB) high burden around the world. The number of MDR-TB patients in Indonesia is increasing every year, but the data regarding ADRs are still limited. Therefore, more data on their characteristics and their management is very valuable for clinicians and pharmacists. METHODS: The study is a descriptive study, using retrospective data of MDR-TB patients who completed therapy from January 1st, 2015 to December 31st, 2015 at the Tuberculosis Outpatient unit at the Dr. Soetomo Teaching Hospital Indonesia. Each adverse effect was judged with standards of the clinic and was documented in patients' medical records. RESULTS: There were 40 patients included in this study. During therapy, 70% of patients developed at least one adverse drug reaction. The five most prevalent adverse effects found in this study were hyperuricemia (52.5%) followed by gastrointestinal (GI) disturbances (40%), ototoxicity (37.5%), hypokalemia (27.5%), and athralgia (12.5%). Managements that were undertaken to overcome the adverse drug reactions were adding symptomatic drugs and/or modifying the treatment regimen. CONCLUSIONS: Because of the small samples we cannot attain a general conclusion. However, the result of this study is very imperative as this data gives us insight regarding adverse effects in MDR-TB patients in Indonesia.


Subject(s)
Drug-Related Side Effects and Adverse Reactions , Tuberculosis, Multidrug-Resistant , Antitubercular Agents/adverse effects , Drug Resistance, Multiple/drug effects , Drug-Related Side Effects and Adverse Reactions/drug therapy , Humans , Retrospective Studies , Tuberculosis, Multidrug-Resistant/drug therapy
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