Recurrence of hypertensive disorders of pregnancy: results from a nationwide prospective cohort study (CONCEPTION).

OBJECTIVE: To assess the risk of gestational hypertension (GH) and pre-eclampsia (PE) during a second pregnancy after occurrence during a first pregnancy. DESIGN: Prospective cohort study. SETTING: CONCEPTION is a French nationwide cohort study that used data from the National Health Data System (SNDS) database. METHODS: We included all women who gave birth for the first time in France in 2010-2018 and who subsequently gave birth. We identified GH and PE through hospital diagnoses and the dispensing of anti-hypertensive drugs. The incidence rate ratios (IRR) of all hypertensive disorder of pregnancy (HDP) during the second pregnancy were estimated using Poisson models adjusted for confounding. MAIN OUTCOME MEASURES: Incidence rate ratios of HDP during the second pregnancy. RESULTS: Of the 2 829 274 women included, 238 506 (8.4%) were diagnosed with HDP during their first pregnancy. In women with GH during their first pregnancy, 11.3% (IRR 4.5, 95% confidence interval [CI] 4.4-4.7) and 3.4% (IRR 5.0, 95% CI 4.8-5.3) developed GH and PE during their second pregnancy, respectively. In women with PE during their first pregnancy, 7.4% (IRR 2.6, 95% CI 2.5-2.7) and 14.7% (IRR 14.3, 95% CI 13.6-15.0) developed GH and PE during their second pregnancy, respectively. The more severe and earlier the PE during the first pregnancy, the stronger the likelihood of having PE during the second pregnancy. Maternal age, social deprivation, obesity, diabetes and chronic hypertension were all associated with PE recurrence. CONCLUSION: These results can guide policymaking that focuses on improving counselling for women who wish to become pregnant more than once, by identifying those who would benefit more from tailored management of modifiable risk factors, and heightened surveillance during post-first pregnancies.

[Screening and healthcare for pregnant women with psycho-social vulnerability : A French national study]. / Dépistage et parcours de soins en cas de vulnérabilités psycho-sociales maternelles : une enquête nationale française.

INTRODUCTION: Psycho-social vulnerabilities are a medical risk factor for both fetus and mother. Association between socioeconomic status and prenatal follow-up has been well established and inadequate follow-up is associated with higher morbidity and mortality in women in unfavorable situations. OBJECTIVE: The objective is to identify screening strategies and to describe existing systems for pregnant women in psycho-social vulnerability in French maternity hospitals. MATERIAL AND METHODES: This is a national survey conducted by questionnaire in all French maternities. RESULTS: Screening by means of targeted questions is carried out by 96.7% of maternity units. Early prenatal interviews are offered systematically by 64% of maternity units and access to them is still difficult for women in vulnerable situations. In order to organize care pathways, 28.7% of maternities have a structured unit within their establishment and 81% state that they have mobilizable caregivers. Multidisciplinary meetings for the coordination of the various stakeholders are held by 85.8% of maternity units. Collaboration with networks and associations is emphasized. CONCLUSION: A large proportion of maternities seek to identify women in situation of psycho-social vulnerabilities and to organize care paths. However, the resources implemented still appear insufficient for many maternity units. Each maternity hospital has resources and is developing initiatives to deal with the difficulties of care.

Is the type 2 diabetes epidemic plateauing in France? A nationwide population-based study.

AIM: Nationwide data on the evolution of diabetes incidence and prevalence are scarce in France. For this reason, our objectives were to determine type 2 diabetes prevalence and incidence rates between 2010 and 2017, stratified by gender, age and region, and to assess annual time trends over the study period in adults aged≥45 years. METHODS: Diabetes cases in the National Health Data System (SNDS), which covers the entire French population (66 million people), were identified through a validated algorithm. Gender- and age-specific prevalence and incidence rates were estimated. Negative binomial models, adjusted for gender, age and region, were used to assess annual time trends for prevalence and incidence throughout the study period. RESULTS: During 2017, 3,144,225 diabetes cases aged≥45 years were identified. Over the study period, prevalence increased slightly (men from 11.5% to 12.1%, women from 7.9% to 8.4%) whereas incidence decreased (men from 11 to 9.7, women from 7.2 to 6.2 per 1000 person-years). In only four groups did prevalence rates decrease: men aged 45-65 years; women aged 45-60 years; women in Reunion; and women in Martinique. An increasing annual time trend was observed for prevalence (men: +0.9% [95% CI: +0.7%, +1%]; women: +0.4% [95% CI: +0.2%, +0.6%]) with a decreasing annual time trend for incidence in both genders (men: -2.6% [95% CI: -3.1%, -2.0%]; women: -3.9% [95% CI: -4.5%, -3.4%]). CONCLUSION: Further efforts towards diabetes prevention are required to ensure that incidence rates in France continue to diminish, as the disorder continues to represent an important public-health burden.

Microscopic study of the Halperin-Laughlin interface through matrix product states.

Interfaces between topologically distinct phases of matter reveal a remarkably rich phenomenology. We study the experimentally relevant interface between a Laughlin phase at filling factor ν = 1/3 and a Halperin 332 phase at filling factor ν = 2/5. Based on our recent construction of chiral topological interfaces (Nat. Commun. https://doi.org/10.1038/s41467-019-09168-z ; 2019), we study a family of model wavefunctions that captures both the bulk and interface properties. These model wavefunctions are built within the matrix product state framework. The validity of our approach is substantiated through extensive comparisons with exact diagonalization studies. We probe previously unreachable features of the low energy physics of the transition. We provide, amongst other things, the characterization of the interface gapless mode and the identification of the spin and charge excitations in the many-body spectrum. The methods and tools presented are applicable to a broad range of topological interfaces.

Model states for a class of chiral topological order interfaces.

Interfaces between topologically distinct phases of matter reveal a remarkably rich phenomenology. To go beyond effective field theories, we study the prototypical example of such an interface between two Abelian states, namely the Laughlin and Halperin states. Using matrix product states, we propose a family of model wavefunctions for the whole system including both bulks and the interface. We show through extensive numerical studies that it unveils both the universal properties of the system, such as the central charge of the gapless interface mode and its microscopic features. It also captures the low energy physics of experimentally relevant Hamiltonians. Our approach can be generalized to other phases described by tensor networks.

Maternal admissions to intensive care units in France: Trends in rates, causes and severity from 2010 to 2014.

INTRODUCTION: Maternal intensive care unit admission is an indicator of severe maternal morbidity. The objective of this study was to estimate rates of maternal intensive care unit admission during or following pregnancy in France, and to describe the characteristics of women concerned, the severity of their condition, associated diagnoses, regional disparities, and temporal trends between 2010 and 2014. METHODS: Women hospitalised in France in intensive care units during pregnancy or up to 42 days after pregnancy between January 2010 and December 2014 were identified using the national hospital discharge database (PMSI-MCO). Trends in incidence rates were quantified using percentages of average annual variation based on a Poisson regression model. RESULTS: In total, 16,011 women were admitted to intensive care units, representing an overall incidence of 3.97‰ deliveries. This number decreased significantly by 1.7% on average per year. For women who gave birth (60.5% by C-section), 62.5% of admissions occurred during their hospitalisation for delivery. The SAPS II score, an indicator of severity, significantly increased from 18.4 in 2010 to 21.5 in 2014. Obstetrical haemorrhage (39.8%) and hypertensive complications during pregnancy (24.8%) were the most common reasons for admission. In mainland France, the Ile-de-France (i.e., greater Paris) region had the highest rates of intensive care units admission (5.05‰) while the Pays-de-la-Loire region had the lowest (2.69‰). CONCLUSION: The rate of maternal intensive care unit admission decreased from 2010 to 2014 in France, with a concomitant increase in case severity. In-depth studies are needed to understand the territorial disparities identified.

Influence of infant feeding patterns over the first year of life on growth from birth to 5 years.

OBJECTIVES: As early-life feeding experiences may influence later health, we aimed to examine relations between feeding patterns over the first year of life and child's growth in the first 5 years of life. METHODS: Our analysis included 1022 children from the EDEN mother-child cohort. Three feeding patterns were previously identified, i.e. 'Later dairy products introduction and use of ready-prepared baby foods' (pattern-1), 'Long breastfeeding, later main meal food introduction and use of home-made foods' (pattern-2) and 'Use of ready-prepared adult foods' (pattern-3). Associations between the feeding patterns and growth [weight, height and body mass index {BMI}] were analysed by multivariable linear regressions. Anthropometric changes were assessed by the final value adjusted for the initial value. RESULTS: Even though infant feeding patterns were not related to anthropometric measurements at 1, 3 and 5 years, high scores on pattern-1 were associated with higher 1-3 years weight and height changes. High scores on pattern-2 were related to lower 0-1 year weight and height changes, higher 1-5 years weight and height changes but not to BMI changes, after controlling for a wide range of potential confounding variables including parental BMI. Scores on pattern-3 were not significantly related to growth. Additional adjustment for breastfeeding duration reduced the strength of the associations between pattern-2 and growth but not those between pattern-1 and height growth. CONCLUSION: Our findings emphasize the relevance of considering infant feeding patterns including breastfeeding duration, age of complementary foods introduction as well as type of foods used when examining effects of early infant feeding practices on later health. © 2017 World Obesity Federation.

Bosonic integer quantum Hall effect in optical flux lattices.

In two dimensions strongly interacting bosons in a magnetic field can realize a bosonic integer quantum Hall state, the simplest two-dimensional example of a symmetry-protected topological phase. We propose a realistic implementation of this phase using an optical flux lattice. Through exact diagonalization calculations, we show that the system exhibits a clear bulk gap and the topological signature of the bosonic integer quantum Hall state. In particular, the calculation of the many-body Chern number leads to a quantized Hall conductance in agreement with the analytical predictions. We also study the stability of the phase with respect to some of the experimentally relevant parameters.

Correlation lengths and topological entanglement entropies of unitary and nonunitary fractional quantum Hall wave functions.

Using the newly developed matrix product state formalism for non-Abelian fractional quantum Hall (FQH) states, we address the question of whether a FQH trial wave function written as a correlation function in a nonunitary conformal field theory (CFT) can describe the bulk of a gapped FQH phase. We show that the nonunitary Gaffnian state exhibits clear signatures of a pathological behavior. As a benchmark we compute the correlation length of a Moore-Read state and find it to be finite in the thermodynamic limit. By contrast, the Gaffnian state has an infinite correlation length in (at least) the non-Abelian sector, and is therefore gapless. We also compute the topological entanglement entropy of several non-Abelian states with and without quasiholes. For the first time in the FQH effect the results are in excellent agreement in all topological sectors with the CFT prediction for unitary states. For the nonunitary Gaffnian state in finite size systems, the topological entanglement entropy seems to behave like that of the composite fermion Jain state at equal filling.

Braiding non-Abelian quasiholes in fractional quantum Hall states.

Quasiholes in certain fractional quantum Hall states are promising candidates for the experimental realization of non-Abelian anyons. They are assumed to be localized excitations, and to display non-Abelian statistics when sufficiently separated, but these properties have not been explicitly demonstrated except for the Moore-Read state. In this work, we apply the newly developed matrix product state technique to examine these exotic excitations. For the Moore-Read and the Z_{3} Read-Rezayi states, we estimate the quasihole radii, and determine the correlation lengths associated with the exponential convergence of the braiding statistics. We provide the first microscopic verification for the Fibonacci nature of the Z_{3} Read-Rezayi quasiholes. We also present evidence for the failure of plasma screening in the nonunitary Gaffnian wave function.

BLOCH model wave functions and pseudopotentials for all fractional Chern insulators.

We introduce a Bloch-like basis in a C-component lowest Landau level fractional quantum Hall (FQH) effect, which entangles the real and internal degrees of freedom and preserves an N(x)×N(y) full lattice translational symmetry. We implement the Haldane pseudopotential Hamiltonians in this new basis. Their ground states are the model FQH wave functions, and our Bloch basis allows for a mutatis mutandis transcription of these model wave functions to the fractional Chern insulator of arbitrary Chern number C, obtaining wave functions different from all previous proposals. For C>1, our wave functions are related to color-dependent magnetic-flux inserted versions of Halperin and non-Abelian color-singlet states. We then provide large-size numerical results for both the C = 1 and C = 3 cases. This new approach leads to improved overlaps compared to previous proposals. We also discuss the adiabatic continuation from the fractional Chern insulator to the FQH in our Bloch basis, both from the energy and the entanglement spectrum perspectives.

Extracting excitations from model state entanglement.

We extend the concept of an entanglement spectrum from the geometrical to the particle bipartite partition. We apply this to several fractional quantum Hall wave functions on both sphere and torus geometries to show that this new type of entanglement spectra completely reveals the physics of bulk quasihole excitations. While this is easily understood when a local Hamiltonian for the model state exists, we show that the quasihole wave functions are encoded within the model state even when such a Hamiltonian is not known. As a nontrivial example, we look at Jain's composite fermion states and obtain their quasiholes directly from the model state wave function. We reach similar conclusions for wave functions described by Jack polynomials.

Topological entanglement in Abelian and non-Abelian excitation eigenstates.

Entanglement in topological phases of matter has so far been investigated through the perspective of their ground-state wave functions. In contrast, we demonstrate that the excitations of fractional quantum Hall (FQH) systems also contain information to identify the system's topological order. Entanglement spectrum of the FQH quasihole (QH) excitations is shown to differentiate between the conformal field theory (CFT) sectors, based on the relative position of the QH with respect to the entanglement cut. For Read-Rezayi model states, as well as Coulomb interaction eigenstates, the counting of the QH entanglement levels in the thermodynamic limit matches exactly the CFT counting, and sector changes occur as non-Abelian quasiholes successively cross the entanglement cut.

Entanglement gap and a new principle of adiabatic continuity.

We give a complete definition of the entanglement gap separating low-energy, topological levels from high-energy, generic ones, in the "entanglement spectrum" of fractional quantum Hall (FQH) states. This is accomplished by removing the magnetic length inherent in the FQH problem--a procedure which we call taking the conformal limit. The counting of the low-lying entanglement levels starts off as the counting of modes of the edge theory of the FQH state, but quickly develops finite-size effects which we find to serve as a fingerprint of the FQH state. As the sphere manifold where the FQH resides grows, the level spacing of the states at the same angular momentum goes to zero, suggestive of the presence of relativistic gapless edge states. By using the adiabatic continuity of the low-entanglement energy levels, we investigate whether two states are topologically connected.

Atypical fractional quantum Hall effect in graphene at filling factor 1/3.

We study, with the help of exact-diagonalization calculations, a four-component trial wave function that may be relevant for the recently observed graphene fractional quantum Hall state at a filling factor ν(G) = 1/3. Although it is adiabatically connected to a 1/3 Laughlin state in the upper spin branch, with SU(2) valley-isospin ferromagnetic ordering and a completely filled lower spin branch, it reveals physical properties beyond such a state that is the natural ground state for a large Zeeman effect. Most saliently, it possesses at experimentally relevant values of the Zeeman gap low-energy spin-flip excitations that may be unveiled in inelastic light-scattering experiments.

Topological entanglement and clustering of Jain hierarchy states.

We obtain several clustering properties of the Jain states at filling k/2k+1: they are a product of a Vandermonde determinant and a bosonic polynomial at filling k/k+1 which vanishes when k+1 particles cluster together. We show that all Jain states satisfy a "squeezing rule" which severely reduces the dimension of the Hilbert space necessary to generate them. We compute the topological entanglement spectrum of the Jain nu=2/5 state and compare it to both the Coulomb ground state and the nonunitary Gaffnian state. All three states have a very similar "low-energy" structure. However, the Jain state entanglement "edge" state counting matches both the Coulomb counting as well as two decoupled U(1) free bosons, whereas the Gaffnian edge counting misses some of the edge states of the Coulomb spectrum.

Conformal field theory approach to Abelian and non-Abelian quantum Hall quasielectrons.

The quasiparticles in quantum Hall liquids carry fractional charge and obey fractional quantum statistics. Of particular recent interest are those with non-Abelian statistics, since their braiding properties could, in principle, be used for robust coding of quantum information. There is already a good theoretical understanding of quasiholes in both Abelian and non-Abelian quantum Hall states. Here we develop conformal field theory methods that allow for an equally precise description of quasielectrons and explicitly construct two- and four-quasielectron excitations of the non-Abelian Moore-Read state.

Anatomy of Abelian and non-Abelian fractional quantum Hall states.

We deduce a new set of symmetries and relations between the coefficients of the expansion of Abelian and non-Abelian fractional quantum Hall (FQH) states in free (bosonic or fermionic) many-body states. Our rules allow us to build an approximation of a FQH model state with an overlap increasing with growing system size (that may sometimes reach unity) while using a fraction of the original Hilbert space. We prove these symmetries by deriving a previously unknown recursion formula for all the coefficients of the Slater expansion of the Laughlin, Read-Rezayi, and many other states (all Jacks multiplied by Vandermonde determinants), which completely removes the current need for diagonalization procedures for these model Hamiltonians.

Bridge between Abelian and non-Abelian fractional quantum Hall states.

We propose a scheme to construct the most prominent Abelian and non-Abelian fractional quantum Hall states from K-component Halperin wave functions. In order to account for a one-component quantum Hall system, these SU(K) colors are distributed over all particles by an appropriate symmetrization. Numerical calculations corroborate the picture that K-component Halperin wave functions may be a common basis for both Abelian and non-Abelian trial wave functions in the study of one-component quantum Hall systems.