Author Correction: High-temperature operation of electrical injection type-II (GaIn)As/Ga(AsSb)/(GaIn)As "W"-quantum well lasers emitting at 1.3 µm.

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High-temperature operation of electrical injection type-II (GaIn)As/Ga(AsSb)/(GaIn)As "W"-quantum well lasers emitting at 1.3 µm.

Electrical injection lasers emitting in the 1.3 µm wavelength regime based on (GaIn)As/Ga(AsSb)/(GaIn)As type-II double "W"-quantum well heterostructures grown on GaAs substrate are demonstrated. The structure is designed by applying a fully microscopic theory and fabricated using metal organic vapor phase epitaxy. Temperature-dependent electroluminescence measurements as well as broad-area edge-emitting laser studies are carried out in order to characterize the resulting devices. Laser emission based on the fundamental type-II transition is demonstrated for a 975 µm long laser bar in the temperature range between 10 °C and 100 °C. The device exhibits a differential efficiency of 41 % and a threshold current density of 1.0 kA/cm2 at room temperature. Temperature-dependent laser studies reveal characteristic temperatures of T0 = (132 ± 3) K over the whole temperature range and T1 = (159 ± 13) K between 10 °C and 70 °C and T1 = (40 ± 1) K between 80 °C and 100 °C.

A dielectric inverse problem applied to human skin measurements during glucose excursions.

A fringing field capacitive sensor has been used to measure the dielectric properties of human skin and underlying tissue in the MHz frequency range. It has recently been shown in clinical experimental studies that these dielectric properties can be related to the effects of in vivo glucose variations of the test subject. Previously, the relationship between electrical impedance and the glucose level has been established via statistical methods, such as the regression method. In this work, we explored a different approach, namely the resolution of the so-called inverse problem. First we applied the method on an artificial two-layer lossy system in order to test the sensitivity of the solution to forced changes in the layer properties and its stability to a constant setting. After validation of this method on artificial systems, a similar inverse problem was set and solved for dielectric measurements on human skin during an induced glucose excursion, where the skin is also modelled as a double-layer system. The changes of the measured permittivity and conductivity of the second layer versus the glucose changes are calculated for 22 study days. The statistical distribution shows that the median slopes of both dielectric properties are negative. These results can be used to test our hypothesis and to continue building potential explanations for the phenomena induced by the glucose changes on the skin layer dielectric parameters.

Fast neutrons produced by nuclear fragmentation in treatment irradiations with 12C beam.

In the framework of the heavy-ion tumour therapy project at GSI we investigated the nuclear fragmentation of 200 AMeV carbon ions stopping in a 12.78-cm thick water absorber. Fast neutrons and charged particles emerging from the target were registered at forward angles between 0 degrees and 30 degrees with a DeltaE-E-telescope consisting of an NE102 and a BaF2 scintillator. We obtained neutron energy spectra and angular distributions and derived the neutron yield in the energy range from 10 to 500 MeV in the forward hemisphere. In addition, we performed fragmentation measurements in actual patient treatment irradiations. The resulting angular distributions of neutrons and charged particles as well as their yields are similar to those obtained with the water absorber.

The fast neutron component in treatment irradiations with 12C beam.

Using 12C beams of 200 AMeV kinetic energy the production of secondary fragments from nuclear reactions in a thick water absorber (12.78 cm) was investigated. Fast neutrons and energetic charged particles (p-, d-, t-, a-particles) emitted in the forward hemisphere were identified by a BaF2/plastic-scintillation detector telescope. Neutron energy spectra were recorded at various angles using time-of-flight techniques. The neutron emission is forward peaked and the energy spectrum shows a broad maximum about half the energy per nucleon of the primary 12C ions. The total yield of fast neutrons emitted into the forward hemisphere integrated over the energy range of 25 to 500 MeV was found to be 0.43 +/- 0.1 per primary ion. The dose contribution of fast neutrons in patient treatments with carbon ions is estimated to be less than 1% of the total treatment dose.

Complications after endovascular repair of type B aortic dissection.

PURPOSE: To outline the complications encountered after endoluminal treatment in patients with type B aortic dissection. METHODS: Between 1999 and 2001, 14 patients (12 men; mean age 60.3 years, range 39-79) with isolated type B aortic dissection (13 chronic, 1 acute) underwent aortic stent-grafting. Three patients with chronic dissection presented an acute clinical picture and were managed emergently. The left subclavian artery was intentionally covered by the prosthesis in 9 patients. Follow-up studies were performed at 6-month intervals. RESULTS: Stent-graft implantation was technically successful in all patients, but incomplete sealing (endoleak) of the entry site required additional proximal stent-graft implantation in 4. The left subclavian artery remained patent in 5 patients. Secondary conversion was required in 3 patients: 2 for acute type A dissection resulting from injury to the aortic arch by Talent endografts and a sustained hemorrhage (left hemothorax). In another patient, a secondary intramural hematoma subsided spontaneously. Anterior spinal artery syndrome in 1 patient persisted at 1 month. No bypass was necessary for the 9 patients with the covered left subclavian arteries. Mean follow-up was 14 months (range 1-23). CONCLUSIONS: Stent-grafting is feasible in patients with type B aortic dissection, although it is associated with a considerable rate of complications. Frank reporting of these sequelae for a variety of stent-grafts is of paramount importance to clarifying the limitations of the method.

A randomized, controlled trial of a simple emergency department intervention to improve the rate of primary care follow-up for patients with acute asthma exacerbations.

STUDY OBJECTIVE: We determined whether a simple emergency department intervention improves the likelihood of primary care provider (PCP) follow-up after ED discharge for an acute asthma exacerbation. METHODS: This randomized, controlled clinical trial was conducted in an urban university-based ED. Participants were patients with asthma between the ages of 16 and 45 years who were treated and discharged from the ED. The study intervention was usual care or an intervention that consisted of a free 5-day course of prednisone, vouchers for transportation to and from their PCP, and a 48-hour telephone reminder to make an appointment with their PCP. The main outcome was whether the patient received follow-up care as determined by PCP contact at 4 weeks. RESULTS: One hundred ninety-two patients with asthma were enrolled over 8 months; 178 (93%) had complete follow-up. The intervention and control groups were similar with regard to age, sex, ethnicity, or years of education. The 2 groups were also comparable with respect to multiple measures of baseline access/barriers to care and severity of ED exacerbation. Patients receiving the intervention were significantly more likely to follow up with their PCP than control patients (relative risk 1.6; 95% confidence interval [CI] 1.1, 2.4). When adjusted for other factors influencing PCP follow-up care (ethnicity, prior PCP relationship, insurance status, regular car access), intervention patients were more likely to follow up with their PCP (odds ratio 3.1; 95% CI 1.5, 6.3). CONCLUSION: Providing medication, transportation vouchers, and a telephone reminder to make an appointment increased the likelihood that discharged patients with asthma obtained PCP follow-up.

Violence between women in an urban emergency department patient population.

OBJECTIVE: To determine what percentage of women presenting to an urban emergency department (ED) for any reason had been the victims of violence committed by another woman in the previous year. METHODS: This was a prospective study of a consecutive sample of female patients of legal age presenting to the ED between 8 AM and 12 midnight over an 11-week period. Patients were asked a series of questions adapted from the George Washington University Universal Violence Prevention Screening Protocol. Non-English-speaking patients, those unable to give informed consent, and those meeting regional criteria for major trauma were excluded. RESULTS: One thousand six hundred seventy-six women participated; 426 (25%) refused. Of the 1,250 women interviewed, 118 (9.4%; 95% CI = 7.8% to 11.1%) reported being assaulted by another woman in the previous 12 months. Compared with the nonvictims, the victims were more frequently younger and single. The most common forms of assault were slapping, grabbing, and shoving (54.7% of victims). These were followed by being choked, kicked, bitten, or punched (46.2%). Eighteen percent of the assaults involved a weapon or an object. Five percent of the victims described being forced to have sex. Thirty-seven percent of the victims contacted the police, 13% required medical attention, 17% pursued legal action, and 10% sought follow-up counseling. CONCLUSIONS: Nine percent of the women in the study sample had been assaulted by another woman in the previous year. Further attention to the recognition and management of violence committed by women against other women may be warranted to ensure that patients receive appropriate treatment and referral.

Polypharmacy. Reducing adverse events among the elderly in NJ.

This is the second of a two-part series that focuses on reducing polypharmacy and adverse drug events in the community-dwelling elderly. Part 2 focuses on the medical exception process (MEP), explains information flow relevant to the physician's practice, and provides clinical examples illustrating the potential of computer technology in improving outcomes of care. A combined approach, which employs computer-based technology, values physician judgment, and stresses patient and provider education, is described.

History of domestic violence among male patients presenting to an urban emergency department.

OBJECTIVE: To establish the prevalence of domestic violence committed by women against male patients presenting to an urban ED for any reason. METHODS: This was a prospective survey in which male patients of legal age presenting to the ED over a 13-week period were interviewed. Patients answered a series of six questions adapted from the George Washington University Universal Violence Prevention Screening Protocol. Patients who could not speak English, those refusing to participate, those unable to give informed consent, and those meeting regional criteria for major trauma were excluded. RESULTS: Of 866 male patients interviewed, 109 (12.6%) had been the victims of domestic violence committed by a female intimate partner within the preceding year. Victims were more likely to be younger, single, African American, and uninsured. The most common forms of assault were slapping, grabbing, and shoving (60.6% of victims). These were followed by choking, kicking, biting, and punching (48.6%), or throwing an object at the victim (46.8%). Thirty-seven percent of cases involved a weapon. Seven percent of victims described being forced to have sex. Nineteen percent of victims contacted the police; 14% required medical attention; 11% pressed charges or sought a restraining order; and 6% pursued follow-up counseling. CONCLUSIONS: Almost 13% of men in this sample population had been victims of domestic violence committed by a female intimate partner within the previous year. Further attention to the recognition and management of domestic violence committed by women against men may be warranted.

M-cadherin and its sisters in development of striated muscle.

Cadherins are calcium-dependent, transmembrane intercellular adhesion proteins with morphoregulatory functions in the development and maintenance of tissues. In the development of striated muscle, the expression and function of mainly M-, N-, and R-cadherin has been studied so far. While these three cadherins are expressed in skeletal muscle cells, of these only N-cadherin is expressed in cardiac muscle. In this review, M-, N-, and R-cadherin are discussed as important players in the terminal differentiation and possibly also in the commitment of skeletal muscle cells. Furthermore, reports are described which evaluate the essential role of N-cadherin in the formation of heart tissue.

Polypharmacy. Reducing adverse events among the elderly in NJ. Part 1.

This is the first of a two-part series that focuses on reducing polypharmacy and adverse drug events in the community-dwelling elderly. Part 1 provides a rationale for the design of public health interventions to reduce this problem and explores technology development. The components of an integrated system linking computer-based technology, pharmacists, and physicians are outlined.

Caregiving as reciprocal exchange in families with seriously mentally ill members.

Caregiving for people with chronic illnesses, including serious mental illnesses, has generally been seen as support that a care provider gives to a dependent receiver. In contrast, this research views caregiving as a process of mutual exchange. It tests the hypothesis that how much support a mentally ill family member receives depends on how much support they provide to other family members. We also examine whether or not reciprocity depends on the role relationship between recipients and providers of care, the level of patient symptomatology, coresidence, and several sociodemographic characteristics. The sample includes 66 patients who have at least one sampled parent or sibling. The results indicate that the amount of support patients give parents and siblings is very strongly associated with how much support they receive from family members. In comparison to the other variables considered here, patient support provision is by far the best predictor of the amount of family support. These results indicate that it is worthwhile to examine caregiving in families with a member who is seriously mentally ill as a process of mutual exchange.

Integrating informatics into the graduate community health nursing curriculum.

Advanced practice of community health nursing is enhanced if the nurse is able to identify, create, and use databases to support nursing assessments of communities and to manage and evaluate community health programs. The College of Nursing, Rutgers, The State University of New Jersey, has revised its curriculum for community health nursing graduate students to include a strong focus on nursing informatics. This paper summarizes the integration of theoretical content and practice exercises into a pre-course workshop and four-course sequence. A focal point of this effort has been the "Healthy People 2000 Nursing Informatics Project," in which students develop an automated community-assessment tool and database related to the Year 2000 objectives. The use of this database and related national, state, and local databases to document community needs is emphasized. Students also evaluate nursing information systems and use information technologies to design and evaluate community health grant proposals. Curriculum development, evaluation, and modification are detailed in relation to student learning needs, faculty preparation, and equipment and consultation requirements.

Ethnic differences in caregiving duties and burdens among parents and siblings of persons with severe mental illnesses.

The policy of community care for the seriously mentally ill increases the caregiving duties and resulting burden on families with members who have a mental illness. Ethnicity is one factor that might have an important impact on the caregiving duties family members perform and the burden that results from these duties. This study uses interviews with 78 parents and 70 siblings of patients scheduled for imminent release from a state mental hospital. The findings indicate that Black and White parents have equivalent caregiving duties, but White parents report substantially more caregiver burden. Black siblings report more caregiving duties than White siblings but report less caregiver burden. These ethnic differences remain after controls for income, gender, age, diagnosis, perceived stigma, and coresidence. The results indicate that ethnicity can be a critical factor affecting levels of informal caretaking for persons with serious mental illnesses.