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Cytotoxic-antineoplastic activity of hydroquinone derivatives.
Molinari, Aurora; Oliva, Alfonso; Reinoso, Paola; del Corral, Jose M Miguel; Castro, M Angeles; Gordaliza, Marina; Gupta, Mahabir P; Solís, Pablo; San Feliciano, Arturo.
Eur J Med Chem ; 37(2): 177-82, 2002 Feb.
Article in English | MEDLINE | ID: mdl-11858850

ABSTRACT

Several myrcenylhydroquinone derivatives have been evaluated for their cytotoxic activity against three neoplastic cell line cultures and compared with the activity previously observed on other neoplastic systems. Also a new series of this type of compounds has been prepared and the compounds synthesised have been evaluated by their GI(50) values.


Subject(s)
Antineoplastic Agents/pharmacology , Hydroquinones/pharmacology , Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/chemistry , Antineoplastic Agents/toxicity , Drug Evaluation, Preclinical , Humans , Hydroquinones/chemical synthesis , Hydroquinones/chemistry , Hydroquinones/toxicity , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Molecular Structure , Structure-Activity Relationship , Tumor Cells, Cultured
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